Simplexins A-I, Eunicellin-Based Diterpenoids from the Soft Coral Klyxum simplex

被引：44

作者：

Wu, Shwu-Li ^{[1
,2
]}

Su, Jui-Hsin ^{[3
]}

Wen, Zhi-Hong ^{[1
]}

Hsu, Chi-Hsin ^{[1
]}

Chen, Bo-Wei ^{[1
]}

Dai, Chang-Feng ^{[4
]}

Kuo, Yao-Haur ^{[5
]}

Sheu, Jyh-Horng ^{[1
,6
]}

机构：

[1] Natl Sun Yat Sen Univ, Dept Marine Biotechnol & Resources, Kaohsiung 804, Taiwan

[2] Natl Kaohsiung Marine Univ, Ctr Gen Studies, Kaohsiung 811, Taiwan

[3] Mei Ho Inst Technol, Dept Biol Sci & Technol, Neipu Hsiang 912, Pingtung, Taiwan

[4] Natl Taiwan Univ, Inst Oceanog, Taipei 112, Taiwan

[5] Natl Res Inst Chinese Med, Taipei 112, Taiwan

[6] Natl Sun Yat Sen Univ, Asia Pacific Ocean Res Ctr, Kaohsiung 804, Taiwan

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

TUMOR-CELL-LINES; PACHYCLAVULARIA-VIOLACEA; TERPENOIDS; ASSAY;

D O I：

10.1021/np900064a

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Nine new eunicellin-based diterpenoids, simplexins A-I (1-9), were isolated from a Dongsha Atoll soft coral, Klyxum simplex. The structures of these compounds were established by detailed spectroscopic analysis (IR, MS, 1D and 2D NMR) and by comparison with the physical and spectral data of related known compounds. The absolute configuration of 1 was determined by a modified Mosher's method. Compounds 1, 4, and 5 were found to be cytotoxic toward a limited panel of cancer cell fines. Compound 5 was shown to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins in LPS-stimulated RAW264.7 macrophage cells.

引用

页码：994 / 1000

页数：7

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