Efficient Photodynamic Therapy of Prostate Cancer Cells through an Improved Targeting of the Cation-Independent Mannose 6-Phosphate Receptor

被引：23

作者：

Bouffard, Elise ^{[1
]}

Jimenez, Chiara Mauriello ^{[2
]}

El Cheikh, Khaled ^{[3
]}

Maynadier, Marie ^{[3
]}

Basile, Ilaria ^{[3
]}

Raehm, Laurence ^{[2
]}

Nguyen, Christophe ^{[1
]}

Gary-Bobo, Magali ^{[1
]}

Garcia, Marcel ^{[1
]}

Durand, Jean-Olivier ^{[2
]}

Morere, Alain ^{[1
]}

机构：

[1] Univ Montpellier, CNRS, IBMM, ENSCM, F-34093 Montpellier, France

[2] Univ Montpellier, CNRS, ENSCM, ICGM, F-34095 Montpellier, France

[3] NanoMedSyn, F-34093 Montpellier, France

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 11期

关键词：

mannose 6-phosphate analogues; binding affinity; mesoporous silica nanoparticles; photodynamic therapy;

D O I：

10.3390/ijms20112809

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the present work is the development of highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for the photodynamic therapy (PDT) of prostate cancer. We chose the strategy to develop a novel compound that allows the improvement of the targeting of the cation-independent mannose 6-phosphate receptor, which is overexpressed in prostate cancer. This original sugar, a dimannoside-carboxylate (M6C-Man) grafted on the surface of MSN for PDT applications, leads to a higher endocytosis and thus increases the efficacy of MSNs.

引用

页数：10

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