Micromanagement: A role for MicroRNAs in mRNA stabitity

被引：21

作者：

Roush, Sarah F.

Slack, Frank J.

机构：

[1] Yale Univ, Dept Mol Cellular & Dev Biol, New Haven, CT 06520 USA

[2] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

ACS CHEMICAL BIOLOGY | 2006年 / 1卷 / 03期

关键词：

D O I：

10.1021/cb600138j

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Small, inhibitory RNA molecules called microRNAs cause large decreases in target protein levels through a posttranscriptional mechanism. Until recently, it was believed this mechanism operated almost exclusively at a step in translation. However, new work has revealed that microRNAs have a second, post-transcriptional mechanism that accelerates the rate of deadenylation, the initial step of mRNA decay.

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页码：132 / 134

页数：3

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