Chromatin conversations: Mechanisms and implications of paramutation

被引：152

作者：

Chandler, VL

Stam, M

机构：

[1] Univ Arizona, Dept Plant Sci, Tucson, AZ 85721 USA

[2] Univ Amsterdam, Swammerdam Inst Life Sci, NL-1098 SM Amsterdam, Netherlands

来源：

NATURE REVIEWS GENETICS | 2004年 / 5卷 / 07期

关键词：

D O I：

10.1038/nrg1378

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Paramutation is a widespread epigenetic phenomenon that was first described in pea and then extensively studied in maize, whereby combining two specific alleles results in a heritable change in the expression of one of the alleles. Far from being restricted to endogenous plant genes, paramutation-like interactions have been described in several kingdoms, in which they can occur between homologous transgenes or between transgenes and homologous endogenous genes at allelic or non-allelic positions. In this review, we discuss potential mechanisms underlying paramutation, compare paramutation to several other trans-sensing phenomena, and speculate on the potential roles and evolutionary implications of these intriguing homology-sensing mechanisms.

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收藏

页码：532 / 544

页数：13

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