Fibulin-3 immunoexpression in malignant mesothelioma due to fluoro-edenite: a preliminary report

被引：10
作者：
Caltabiano, Rosario [1 ]
Loreto, Carla [2 ]
Vitale, Ermanno [3 ]
Matera, Serena [3 ]
Miozzi, Edoardo [3 ]
Migliore, Marcello [4 ]
Angelico, Giuseppe [1 ]
Tumino, Rosario [5 ]
Ledda, Caterina [3 ]
Rapisarda, Venerando [3 ]
机构：
[1] Univ Catania, Sect Anat Pathol, Dept GF Ingrassia, Catania, Italy
[2] Univ Catania, Sect Anat & Histol, Dept Biomed & Biotechnol Sci, Catania, Italy
[3] Univ Catania, Dept Clin & Expt Med, Occupat Med, Catania, Italy
[4] Univ Catania, Univ Hosp Policlin Vittorio Emanuele, Acad Thorac Surg Unit, Dept Surg, Catania, Italy
[5] ASP Ragusa, Civ MP Arezzo Hosp, Canc Registry & Histopathol Dept, Ragusa, Italy
来源：
FUTURE ONCOLOGY | 2018年 / 14卷 / 06期
关键词：
asbestos; biomarkers; EFEMP-1; molecular oncology; oncogenes; PLEURAL MESOTHELIOMA; ASBESTOS; EXPOSURE; FIBERS; BIOMARKER; PLAQUES; SERUM;
D O I：
10.2217/fon-2017-0386
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An increased standardized incidence and mortality rate were reported due to malignant mesothelioma (MM) in Biancavilla. Environmental investigations showed the presence of an asbestiform fiber: fluoro-edenite (FE). MM develops with a latency of 20-60years from exposure and specific and sensitive biomarkers are urgently needed. For this purpose, we evaluated Fibulin-3 (Fb-3) immunoexpression in human cases of MM related to FE exposure and its prognostic role. Immunohistochemical analysis of Fb-3 was carried out in eight MM patients resident in Biancavilla and the analysis showed evidence of environmental exposure to FE fibers. Six MM cases (3 epithelioid and 3 biphasic) showed a high immunoexpression of Fb-3 in neoplastic cells with nuclear and cytoplasmic localization. One epithelioid and one biphasic subtype did not show Fb-3 immunostaining. The results demonstrate the implication of Fb-3 in MM due to FE exposure and may possibly suggest its potential role as a diagnostic and prognostic marker.
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收藏
页码：53 / 57
页数：6
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