共 50 条
Metabolic regulator LKB1 is crucial for Schwann cell-mediated axon maintenance
被引:152
作者:

Beirowski, Bogdan
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

论文数: 引用数:
h-index:
机构:

Golden, Judith P.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Pain Ctr, Dept Anesthesiol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

Chen, Ying-Jr
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Dept Chem, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

Yang, Kui
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

Gross, Richard W.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

Patti, Gary J.
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
Washington Univ, Dept Chem, St Louis, MO 63110 USA
Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA

Milbrandt, Jeffrey
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
机构:
[1] Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[2] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA
[3] Washington Univ, Pain Ctr, Dept Anesthesiol, St Louis, MO 63110 USA
[4] Washington Univ, Dept Chem, St Louis, MO 63110 USA
[5] Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA
[6] Washington Univ, Sch Med, Hope Ctr Neurol Disorders, St Louis, MO 63110 USA
基金:
美国国家卫生研究院;
关键词:
ACTIVATED PROTEIN-KINASE;
HEMATOPOIETIC STEM-CELLS;
DIABETIC-NEUROPATHY;
ENERGY HOMEOSTASIS;
AMPK;
PATHWAY;
MTOR;
MYELINATION;
SUPPORT;
NEURONS;
D O I:
10.1038/nn.3809
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Schwann cells (SCs) promote axonal integrity independently of myelination by poorly understood mechanisms. Current models suggest that SC metabolism is critical for this support function and that SC metabolic deficits may lead to axonal demise. The LKB1-AMP-activated protein kinase (AMPK) kinase pathway targets several downstream effectors, including mammalian target of rapamycin (mTOR), and is a key metabolic regulator implicated in metabolic diseases. We found through molecular, structural and behavioral characterization of SC-specific mutant mice that LKB1 activity is central to axon stability, whereas AMPK and mTOR in SCs are largely dispensable. The degeneration of axons in LKB1 mutants was most dramatic in unmyelinated small sensory fibers, whereas motor axons were comparatively spared. LKB1 deletion in SCs led to abnormalities in nerve energy and lipid homeostasis and to increased lactate release. The latter acts in a compensatory manner to support distressed axons. LKB1 signaling is essential for SC-mediated axon support, a function that may be dysregulated in diabetic neuropathy.
引用
收藏
页码:1351 / 1361
页数:11
相关论文
共 50 条
[1]
c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration
[J].
Arthur-Farraj, Peter J.
;
Latouche, Morwena
;
Wilton, Daniel K.
;
Quintes, Susanne
;
Chabrol, Elodie
;
Banerjee, Annbily
;
Woodhoo, Ashwin
;
Jenkins, Billy
;
Rahman, Mary
;
Turmaine, Mark
;
Wicher, Grzegorz K.
;
Mitter, Richard
;
Greensmith, Linda
;
Behrens, Axel
;
Raivich, Gennadij
;
Mirsky, Rhona
;
Jessen, Kristjan R.
.
NEURON,
2012, 75 (04)
:633-647

Arthur-Farraj, Peter J.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Latouche, Morwena
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Wilton, Daniel K.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Quintes, Susanne
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Chabrol, Elodie
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Banerjee, Annbily
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Woodhoo, Ashwin
论文数: 0 引用数: 0
h-index: 0
机构:
CICbioGune, Metabol Unit, Derio 48160, Bizcaia, Spain UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Jenkins, Billy
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Rahman, Mary
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Turmaine, Mark
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Wicher, Grzegorz K.
论文数: 0 引用数: 0
h-index: 0
机构:
Uppsala Univ, Dept Immunol Genet & Pathol, Neurooncol Grp, S-75185 Uppsala, Sweden UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Mitter, Richard
论文数: 0 引用数: 0
h-index: 0
机构:
CRUK, London Res Inst, Mammalian Genet Lab, London WC2A 3LY, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Greensmith, Linda
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Inst Neurol, Sobell Dept Motor Neurosci & Movement Disorders, London WC1N 3BG, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Behrens, Axel
论文数: 0 引用数: 0
h-index: 0
机构:
CRUK, London Res Inst, Mammalian Genet Lab, London WC2A 3LY, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Raivich, Gennadij
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Perinatal Brain Grp, Dept Obstet & Gynaecol, London WC1E 6BT, England
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Mirsky, Rhona
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England

Jessen, Kristjan R.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Dept Cell & Dev Biol, London WC1E 6BT, England UCL, Dept Cell & Dev Biol, London WC1E 6BT, England
[2]
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
[J].
Barnes, Anthony P.
;
Lilley, Brendan N.
;
Pan, Y. Albert
;
Plummer, Lisa J.
;
Powell, Ashton W.
;
Raines, Alexander N.
;
Sanes, Joshua R.
;
Polleux, Franck
.
CELL,
2007, 129 (03)
:549-563

Barnes, Anthony P.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Lilley, Brendan N.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Pan, Y. Albert
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Plummer, Lisa J.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Powell, Ashton W.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Raines, Alexander N.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Sanes, Joshua R.
论文数: 0 引用数: 0
h-index: 0
机构: Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA

Polleux, Franck
论文数: 0 引用数: 0
h-index: 0
机构:
Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA Univ N Carolina, Ctr Neurosci, Dept Pharmacol, Chapel Hill, NC 27599 USA
[3]
Concepts for regulation of axon integrity by enwrappin gglia
[J].
Beirowski, Bogdan
.
FRONTIERS IN CELLULAR NEUROSCIENCE,
2013, 7

Beirowski, Bogdan
论文数: 0 引用数: 0
h-index: 0
机构:
Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA Washington Univ, Sch Med, Dept Genet, St Louis, MO 63110 USA
[4]
Primary cilia regulate mTORC1 activity and cell size through Lkb1
[J].
Boehlke, Christopher
;
Kotsis, Fruzsina
;
Patel, Vishal
;
Braeg, Simone
;
Voelker, Henriette
;
Bredt, Saskia
;
Beyer, Theresa
;
Janusch, Heike
;
Hamann, Christoph
;
Goedel, Markus
;
Mueller, Klaus
;
Herbst, Martin
;
Hornung, Miriam
;
Doerken, Mara
;
Koettgen, Michael
;
Nitschke, Roland
;
Igarashi, Peter
;
Walz, Gerd
;
Kuehn, E. Wolfgang
.
NATURE CELL BIOLOGY,
2010, 12 (11)
:1115-U126

Boehlke, Christopher
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Kotsis, Fruzsina
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Patel, Vishal
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Dallas, SW Med Ctr, Div Nephrol, Dallas, TX 75390 USA Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Braeg, Simone
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Voelker, Henriette
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Bredt, Saskia
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Beyer, Theresa
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Janusch, Heike
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Hamann, Christoph
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Goedel, Markus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Mueller, Klaus
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Herbst, Martin
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Hornung, Miriam
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Doerken, Mara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Koettgen, Michael
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Nitschke, Roland
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Life Imaging Ctr, Ctr Biol Syst Anal, D-79104 Freiburg, Germany
Univ Freiburg, Ctr Biol Signalling Studies BIOSS, D-79108 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

Igarashi, Peter
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Dallas, SW Med Ctr, Div Nephrol, Dallas, TX 75390 USA Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany

论文数: 引用数:
h-index:
机构:

Kuehn, E. Wolfgang
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany Univ Freiburg, Renal Unit, Dept Med, Univ Med Ctr, D-79106 Freiburg, Germany
[5]
The regulation and function of mammalian AMPK-related kinases
[J].
Bright, N. J.
;
Thornton, C.
;
Carling, D.
.
ACTA PHYSIOLOGICA,
2009, 196 (01)
:15-26

Bright, N. J.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England

Thornton, C.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England

Carling, D.
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England MRC, Ctr Clin Sci, Cellular Stress Grp, London W12 0NN, England
[6]
The regulation of AMP-activated protein kinase by upstream kinases
[J].
Carling, D.
;
Sanders, M. J.
;
Woods, A.
.
INTERNATIONAL JOURNAL OF OBESITY,
2008, 32 (Suppl 4)
:S55-S59

Carling, D.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Hammersmith Hosp,Cellualr Stress Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Hammersmith Hosp,Cellualr Stress Grp, London W12 0NN, England

论文数: 引用数:
h-index:
机构:

Woods, A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Hammersmith Hosp,Cellualr Stress Grp, London W12 0NN, England Univ London Imperial Coll Sci Technol & Med, MRC, Ctr Clin Sci, Hammersmith Hosp,Cellualr Stress Grp, London W12 0NN, England
[7]
The role of aberrant mitochondrial bioenergetics in diabetic neuropathy
[J].
Chowdhury, Subir K. Roy
;
Smith, Darrell R.
;
Fernyhough, Paul
.
NEUROBIOLOGY OF DISEASE,
2013, 51
:56-65

Chowdhury, Subir K. Roy
论文数: 0 引用数: 0
h-index: 0
机构:
St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada

Smith, Darrell R.
论文数: 0 引用数: 0
h-index: 0
机构:
St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada

Fernyhough, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada
Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB, Canada St Boniface Hosp Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2AL, Canada
[8]
Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes
[J].
Chowdhury, Subir K. Roy
;
Dobrowsky, Rick T.
;
Femyhough, Paul
.
MITOCHONDRION,
2011, 11 (06)
:845-854

Chowdhury, Subir K. Roy
论文数: 0 引用数: 0
h-index: 0
机构:
St Boniface Gen Hosp, Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada St Boniface Gen Hosp, Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada

Dobrowsky, Rick T.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Kansas, Dept Pharmacol & Toxicol, Lawrence, KS 66045 USA St Boniface Gen Hosp, Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada

Femyhough, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
St Boniface Gen Hosp, Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada
Univ Manitoba, Dept Pharmacol & Therapeut, Winnipeg, MB R3E 0T6, Canada St Boniface Gen Hosp, Res Ctr, Div Neurodegenerat Disorders, Winnipeg, MB R2H 2A6, Canada
[9]
Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models
[J].
Chrast, Roman
;
Saher, Gesine
;
Nave, Klaus-Armin
;
Verheijen, Mark H. G.
.
JOURNAL OF LIPID RESEARCH,
2011, 52 (03)
:419-434

Chrast, Roman
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland

Saher, Gesine
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Expt Med, Dept Neurogenet, Gottingen, Germany Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland

Nave, Klaus-Armin
论文数: 0 引用数: 0
h-index: 0
机构:
Max Planck Inst Expt Med, Dept Neurogenet, Gottingen, Germany Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland

Verheijen, Mark H. G.
论文数: 0 引用数: 0
h-index: 0
机构:
Vrije Univ Amsterdam, Ctr Neurogenom & Cognit Res, Dept Mol & Cellular Neurobiol, Amsterdam, Netherlands Univ Lausanne, Dept Med Genet, CH-1015 Lausanne, Switzerland
[10]
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
[J].
Contreras, Cristina M.
;
Gurumurthy, Sushma
;
Haynie, J. Marshall
;
Shirley, Lane J.
;
Akbay, Esra A.
;
Wingo, Shana N.
;
Schorge, John O.
;
Broaddus, Russell R.
;
Wong, Kwok-Kin
;
Bardeesy, Nabeel
;
Castrillon, Diego H.
.
CANCER RESEARCH,
2008, 68 (03)
:759-766

Contreras, Cristina M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Gurumurthy, Sushma
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Dept Med, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Haynie, J. Marshall
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Shirley, Lane J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Akbay, Esra A.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Wingo, Shana N.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Obstet & Gynecol, Div Gynecol & Oncol, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Schorge, John O.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Dept Obstet & Gynecol, Div Gynecol & Oncol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Hamon Ctr Therapeut Oncol Res, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Broaddus, Russell R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas Houston, MD Anderson Canc Ctr, Dept Pathol, Houston, TX 77030 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Wong, Kwok-Kin
论文数: 0 引用数: 0
h-index: 0
机构:
Harvard Univ, Sch Med, Boston, MA USA
Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Bardeesy, Nabeel
论文数: 0 引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Dept Med, Boston, MA USA
Harvard Univ, Sch Med, Boston, MA USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA

Castrillon, Diego H.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA
Univ Texas SW Med Ctr Dallas, Simmons Comprehens Canc Ctr, Dallas, TX 75390 USA Univ Texas SW Med Ctr Dallas, Dept Pathol, Dallas, TX 75390 USA