Antigen-Specific Blockade of Lethal CD8 T-Cell Mediated Autoimmunity in a Mouse Model of Multiple Sclerosis

被引：11

作者：

Na, Shin-Young ^{[1
]}

Eujen, Heike ^{[1
]}

Goebel, Kerstin ^{[2
]}

Meuth, Sven G. ^{[2
]}

Martens, Kati ^{[1
]}

Wiendl, Heinz ^{[2
]}

Huenig, Thomas ^{[1
]}

机构：

[1] Univ Wurzburg, Inst Virol & Immunobiol, D-8700 Wurzburg, Germany

[2] Univ Wurzburg, Dept Neurol, D-8700 Wurzburg, Germany

来源：

JOURNAL OF IMMUNOLOGY | 2009年 / 182卷 / 10期

关键词：

MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; POSITIVE SELECTION; CLONAL EXPANSIONS; RESPONSES; COMPLEX; OLIGODENDROCYTES; PEPTIDES; MICE; ENCEPHALOMYELITIS;

D O I：

10.4049/jimmunol.0804200

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Increasing evidence implies CD8 T cells in tissue-specific autoimmune diseases including multiple sclerosis. mAbs specific for MHC class I molecules presenting a dominant autoantigenic peptide may allow selective immunotherapy in such settings. We demonstrate the prophylactic and therapeutic efficacy of such a mAb in a transgenic mouse model of lethal demyelinating disease in which a neo-self Ag expressed by oligodendrocytes is targeted by CD8 T cells with transgenic Ag receptors. Mechanistic studies performed in vitro and in vivo indicate that it is the low expression of MHC class I on oligodendrocytes, which makes this form of Ag-specific intervention possible. The Journal of Immunology, 2009, 182: 6569-6575.

引用

页码：6569 / 6575

页数：7

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