What is the risk of aluminium as a neurotoxin?

被引：75
作者：
Exley, Christopher [1 ]
机构：
[1] Keele Univ, Birchall Ctr, Lennard Jones Labs, Keele, Staffs, England
来源：
EXPERT REVIEW OF NEUROTHERAPEUTICS | 2014年 / 14卷 / 06期
关键词：
aluminium; Alzheimer's disease; body burden; brain; neurotoxin; BRAIN; DISEASE; IRON;
D O I：
10.1586/14737175.2014.915745
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Aluminium is neurotoxic. Its free ion, Al3+ ((aq)), is highly biologically reactive and uniquely equipped to do damage to essential cellular (neuronal) biochemistry. This unequivocal fact must be the starting point in examining the risk posed by aluminium as a neurotoxin in humans. Aluminium is present in the human brain and it accumulates with age. The most recent research demonstrates that a significant proportion of individuals older than 70 years of age have a potentially pathological accumulation of aluminium somewhere in their brain. What are the symptoms of chronic aluminium intoxication in humans? What if neurodegenerative diseases such as Alzheimer's disease are the manifestation of the risk of aluminium as a neurotoxin? How might such an (outrageous) hypothesis be tested?
引用
收藏
页码：589 / 591
页数：3
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