A simple mitochondrial targeting AIEgen for image-guided two-photon excited photodynamic therapy

被引：88
作者：
Jiang, Meijuan [1 ,2 ]
Kwok, Ryan T. K. [1 ,2 ]
Li, Xuesong [3 ,4 ]
Gui, Chen [1 ,2 ]
Lam, Jacky W. Y. [1 ,2 ]
Qu, Jianan [3 ,4 ]
Tang, Ben Zhong [1 ,2 ,5 ]
机构：
[1] Hong Kong Univ Sci & Technol, Hong Kong Branch Chinese Natl Engn, Res Ctr Tissue Restorat & Reconstruct,Dept Chem,D, Inst Adv Study,Inst Mol Funct Mat,State Key Lab M, Kowloon, Hong Kong, Peoples R China
[2] HKUST Shenzhen Res Inst, Guangdong Prov Key Lab Brain Sci Dis & Drug Dev, 9 Yuexing 1st RD,Hitech Pk, Shenzhen 518057, Peoples R China
[3] Hong Kong Univ Sci & Technol, Sch Sci, Ctr Syst Biol & Human Hlth, Dept Elect & Comp Engn, Kowloon, Hong Kong, Peoples R China
[4] Hong Kong Univ Sci & Technol, Inst Adv Study, Kowloon, Hong Kong, Peoples R China
[5] South China Univ Technol, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Lab, Guangdong Innovat Res Team, Guangzhou 510640, Guangdong, Peoples R China
来源：
JOURNAL OF MATERIALS CHEMISTRY B | 2018年 / 6卷 / 17期
关键词：
AGGREGATION-INDUCED EMISSION; ABSORPTION CROSS-SECTIONS; LIGHT-UP PROBE; IN-VITRO; ORGANIC NANOPARTICLES; CARCINOMA-CELLS; PHOTOSENSITIZERS; MECHANISMS; EXCITATION; APOPTOSIS;
D O I：
10.1039/c7tb02609a
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Two-photon excited photodynamic therapy (TP-PDT) is not only able to offer deeper penetration depth but also much more precise 3D treatment than traditional one-photon excited PDT. However, the achievement of TP-PDT requires photosensitizers with large two-photon absorption cross sections, efficient generation of reactive oxygen species, and bright two-photon fluorescence. In this work, we present a simple AIE luminogen (AIEgen), IQ-TPA, with mitochondrial targeting and susceptible two-photon excitation for image-guided photodynamic therapy in cancer cells. This feasibility of utilizing small molecular multifunctional AIEgens for TP-PDT was demonstrated together with the merits of tiny size, good cell permeability, low dark cytotoxicity and easy synthesis, showing great potential for the development of future theranostic systems.
引用
收藏
页码：2557 / 2565
页数：9
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