MicroRNAs and cancer

被引：6

作者：

Kisseljov, F. L. ^{[1
]}

机构：

[1] Russian Acad Med Sci, Blokhin Canc Res Ctr, Moscow 115478, Russia

来源：

MOLECULAR BIOLOGY | 2014年 / 48卷 / 02期

关键词：

tumors; microRNA; biogenesis; expression; functions; diagnostics; prognostic markers; PROGNOSTIC-SIGNIFICANCE; EXPRESSION PROFILES; TUMOR-SUPPRESSOR; GENETIC-VARIANTS; NONCODING RNAS; METASTASIS; PLASMA; CELLS; IDENTIFICATION; SIGNATURES;

D O I：

10.1134/S0026893314020083

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The review is devoted to analyzing the data on the role of microRNAs in human tumor progression. The following topics are thoroughly discussed in the review: (1) general characteristics of microRNAs; (2) their expression pattern in human tumors and specificity of this expression; (3) the possible role of microRNAs as oncogenes and tumor growth suppressors; and (4) their participation in the processes responsible for the transformed phenotype of tumor cells; and (5) the role of microRNAs in early diagnostics of the disease and its prognosis.

引用

页码：197 / 206

页数：10

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