MOM-protected 3-hydroxy-5-phenyl-isoxazole: Regioselective preparation and synthetic application

被引：6

作者：

Alzeer, J ^{[1
]}

Nock, N ^{[1
]}

Wassner, G ^{[1
]}

Masciadri, R ^{[1
]}

机构：

[1] F HOFFMAN LAROCHE LTD, PHARMA RES PRECLIN, INFECT DIS, CH-4070 BASEL, SWITZERLAND

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 38期

关键词：

D O I：

10.1016/0040-4039(96)01547-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Highly regioselective (>90%) MOM-protection of 3-hydroxy-5-phenyl-isoxazole, followed by elaboration in 4-position via directed ortho-metalation and mild deprotection with cold methanolic HCl provided ready access to a series of zwitterionic isoxazole derivatives. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：6857 / 6860

页数：4

共 16 条

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