Studies on Serum of Arsenic Trioxide Treated Rats by 1H NMR Based Metabonomics

被引：1

作者：

Zhang Pan-Pan ^{[1
,2
]}

Zhang Wen-Jun ^{[1
]}

Xue Rong ^{[2
]}

Li Xiao-Jing ^{[2
]}

Yan Wei ^{[3
]}

Pei Feng-Kui ^{[2
]}

机构：

[1] Hebei Univ Technol, Dept Chem, Tianjin 300130, Peoples R China

[2] Chinese Acad Sci, Changchun Inst Appl Chem, Changchun 130022, Peoples R China

[3] Changchun Univ Tradit Chinese Med, Affiliated Hosp, Changchun 130021, Peoples R China

来源：

CHINESE JOURNAL OF ANALYTICAL CHEMISTRY | 2013年 / 41卷 / 09期

关键词：

Metabonomics; Arsenic trioxide; Nuclear magnetic resonance; Serum; Principal component analysis; OXIDATIVE STRESS; SPECTROSCOPY; METABOLISM; INDUCTION; TOXICITY; SYSTEMS; URINE; CELLS; ACID;

D O I：

10.3724/SP.J.1096.2013.21227

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The metabolites of rats' serum caused by arsenic trioxide intragastric infusion (dosed at 2, 10 mg/kg body weight, respectively) were investigated through metabonomics. The metabolic profiling detected by NMR subjected to principal component analysis (PCA), which find out the different metabolites of the control group and arsenic trioxide treated group, to explore the acute biological effects. The results revealed that arsenic trioxide caused acute damage on rats' liver, and the toxicity effect increased with the increase of dose. Low dosage administration arsenic trioxide gave rise to reactive oxygen species (ROS), and high dosage administration arsenic trioxide induced cell apoptosis. Sugar, amino acid fat metabolism disorder and energy metabolism abnormality occurred in both low and high dosed rats.

引用

页码：1434 / 1438

页数：5

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