Boolean network representation of a continuous-time system and finite-horizon optimal control: application to the single-gene regulatory system for the lac operon

被引：9

作者：

Menini, Laura ^{[1
]}

Possieri, Corrado ^{[1
]}

Tornambe, Antonio ^{[1
]}

机构：

[1] Univ Roma Tor Vergata, Dipartimento Ingn Civile & Ingn Informat, Via Politecn 1, Rome, Italy

来源：

INTERNATIONAL JOURNAL OF CONTROL | 2017年 / 90卷 / 03期

关键词：

Boolean network; optimization; lac operon single-gene regulatory system; CELLULAR CONTROL PROCESSES; CATABOLITE REPRESSION; INDUCER EXCLUSION; ESCHERICHIA-COLI; LACTOSE; FEEDBACK; MODEL; BISTABILITY; MATHEMATICS; DYNAMICS;

D O I：

10.1080/00207179.2016.1186289

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

In this paper, the single-gene regulatory system for the lac operon is considered and a method to build a Boolean network able to represent its dynamics is given. A procedure, based on techniques borrowed from algebraic geometry, to compute an optimal control policy minimising a cost function is given for such a Boolean network. A tool to apply such an optimal control policy to the continuous time system is reported. The proposed control method is tested in two simulative examples.

引用

页码：519 / 552

页数：34

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