Pathophysiological role of neutrophils in acute myocardial infarction

被引：147

作者：

Carbone, Federico ^{[1
]}

Nencioni, Alessio ^{[1
]}

Mach, Francois ^{[2
]}

Vuilleumier, Nicolas ^{[3
,4
]}

Montecucco, Fabrizio ^{[1
,2
]}

机构：

[1] Univ Genoa, Dept Internal Med, Genoa, Italy

[2] Univ Hosp Geneva, Fdn Med Researches, Div Cardiol, Fac Med,Dept Internal Med, Geneva, Switzerland

[3] Univ Hosp Geneva, Dept Genet & Lab Med, Div Lab Med, Geneva, Switzerland

[4] Geneva Fac Med, Dept Human Prot Sci, Geneva, Switzerland

来源：

THROMBOSIS AND HAEMOSTASIS | 2013年 / 110卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Atherosclerosis; neutrophils; inflammation; acute myocardial infarction; CORONARY-ARTERY-DISEASE; APOLIPOPROTEIN-A-I; HUMAN ATHEROSCLEROTIC LESIONS; ISCHEMIA-REPERFUSION INJURY; ENDOTHELIAL-CELL-ADHESION; HYPOCHLORITE-MODIFIED PROTEINS; MULTIPLE COMPLEX STENOSES; HIGH-DENSITY-LIPOPROTEIN; APOE-DEFICIENT MICE; C-REACTIVE PROTEIN;

D O I：

10.1160/TH13-03-0211

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogenesis of acute myocardial infarction is known to be me: diated by systemic, intraplaque and myocardial inflammatory processes. Among different immune cell subsets, compelling evidence now indicates a pivotal role for neutrophils in acute coronary syndromes. Neutrophils infiltrate coronary plaques and the infarcted myocardium and mediate tissue damage by releasing matrix-degrading enzymes and reactive oxygen species. In addition, neutrophils are also involved in post-infarction adverse cardiac remodelling and neointima formation after angioplasty. The promising results obtained in preclinical models with pharmacological approaches interfering with neutrophil recruitment or function have confirmed the patho-physiological relevance of these immune cells in acute coronary syndromes and prompted further studies of these therapeutic interventions. This narrative review will provide an update on the role of neutrophils in acute myocardial infarction and on the pharmacological means that were devised to prevent neutrophil-mediated tissue damage and to reduce post-ischaemic outcomes.

引用

页码：501 / 514

页数：14

共 206 条

[1] Mouse neutrophils are professional antigen-presenting cells programmed to instruct Th1 and Th17 T-cell differentiation [J].