Cathode photoelectrochemical immunoassay based on analyte-induced formation of exciton trapping for carcinoembryonic antigen detection

被引：12

作者：

Wen, Guangming ^{[1
]}

Yang, Xiaojie ^{[1
]}

Xi, Xiaoli ^{[2
]}

机构：

[1] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Peoples R China

[2] Shanxi Univ, Inst Mol Sci, Taiyuan 030006, Peoples R China

来源：

JOURNAL OF ELECTROANALYTICAL CHEMISTRY | 2015年 / 757卷

基金：

中国国家自然科学基金;

关键词：

Photoelectrochemical; Immunoassay; Quantum dots; CuO NPs; Carcinoembryonic antigen; QUANTUM DOTS; VISIBLE-LIGHT; ELECTROCHEMICAL IMMUNOASSAY; NANOPARTICLES; COPPER(II); BIOSENSORS; NANOTUBES; SENSORS;

D O I：

10.1016/j.jelechem.2015.09.039

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A simple and sensitive sandwich-type photoelectrochemical (PEC) biosensor with CuO NPs labeled antibody for detection of protein was constructed. The approach relies on antibodies modified by CuO NPs which could release copper ions. In the presence of the target protein, the released copper ions help form the trapping sites to interfere with quantum confinement of quantum dots (QDs) and thus blocked the escape of photoelectron, leading to a "signal off' PEC method for sensitive detection. This work opens a novel highly sensitive way to detect cancer biomarker carcinoembryonic antigen (CEA) and provides an efficient applicable tool for PEC bioanalysis. (C) 2015 Published by Elsevier B.V.

引用

页码：192 / 197

页数：6

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