Efficacy of Conversion Surgery Following S-1 plus Cisplatin or Oxaliplatin Chemotherapy for Unresectable Gastric Cancer

被引：12

作者：

Fukuchi, Minoru ^{[1
]}

Mochiki, Erito ^{[1
]}

Ishiguro, Toru ^{[1
]}

Ogura, Toshiro ^{[1
]}

Sobajima, Jun ^{[1
]}

Kumagai, Youichi ^{[1
]}

Ishibashi, Keiichiro ^{[1
]}

Ishida, Hideyuki ^{[1
]}

机构：

[1] Saitama Med Univ, Saitama Med Ctr, Dept Digest Tract & Gen Surg, 1981 Kamoda, Kawagoe, Saitama 3508550, Japan

来源：

ANTICANCER RESEARCH | 2017年 / 37卷 / 03期

关键词：

Unresectable gastric cancer; conversion surgery; chemotherapy; ADJUVANT SURGERY; PHASE-III; THERAPY; TRIAL;

D O I：

10.21873/anticanres.11453

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background/Aim: To evaluate the efficacy of conversion surgery following S-1 plus cisplatin (CS) or oxaliplatin (SOX) chemotherapy. Patients and Methods: We retrospectively analyzed clinicopathological and survival data of 74 patients with unresectable gastric cancer receiving CS or SOX. Results: Fifty-five and nineteen patients received CS and SOX, respectively. Conversion surgery (odds ratio (OR), 0.17; 95% confidence interval (CI), 0.04-0.64; p=0.01) was the only significant independent predictor of longer survival in multivariate Cox regression analysis. Patients (median age, 74 years) receiving SOX were significantly older than those receiving CS (median age=67 years) (p<0.01), although the rates of response, severe toxicity or conversion surgery did not differ significantly between the two treatment groups. Conclusion: Conversion surgery after a response to CS or SOX chemotherapy may have survival benefit in selected unresectable gastric cancer patients, for both non-elderly and elderly patients responding to SOX.

引用

页码：1343 / 1347

页数：5

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