Heterogeneous gold(I)-catalyzed cyclization between ynals and amidines: An efficient and practical synthesis of 2,4-disubstituted pyrimidines

被引：7
作者：
Jiang, Minhua [1 ,2 ,3 ]
Nie, Quan [1 ,2 ]
Cai, Mingzhong [1 ,2 ]
机构：
[1] Jiangxi Normal Univ, Key Lab Funct Small Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China
[2] Jiangxi Normal Univ, Coll Chem & Chem Engn, Nanchang 330022, Jiangxi, Peoples R China
[3] Xinyu Univ, Sch New Energy Sci & Engn, Xinyu, Peoples R China
来源：
SYNTHETIC COMMUNICATIONS | 2019年 / 49卷 / 19期
基金：
中国国家自然科学基金;
关键词：
Cyclization; gold; heterogeneous catalysis; pyrimidine; ynal; GOLD-CATALYZED SYNTHESIS; FUNCTIONALIZED OXAZOLES; INHIBITORS SYNTHESIS; PROPARGYLIC AMIDES; TANDEM REACTIONS; PYRROLES; COMPLEXES; DISCOVERY; REAGENTS; STRATEGY;
D O I：
10.1080/00397911.2019.1631347
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel and highly efficient heterogeneous gold(I)-catalyzed cyclization between ynals and amidines has been developed that proceeds smoothly under mild conditions and provides a general and practical method for the synthesis of a wide variety of 2,4-disubstituted pyrimidines with high atom-economy, good to high yield, and recyclability of the gold(I) catalyst. The present method is an attractive alternative to construct substituted pyrimidines.
引用
收藏
页码：2488 / 2500
页数：13
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