Pharmacogenomics and Pharmacogenetics: In Silico Prediction of Drug Effects in Treatments for Novel Coronavirus SARS-CoV2 Disease

被引：13

作者：

Cafiero, Concetta ^{[1
]}

Re, Agnese ^{[2
]}

Micera, Alessandra ^{[3
]}

Palmirotta, Raffaele ^{[4
]}

Monaco, Delio ^{[5
]}

Romano, Francesca ^{[6
]}

Fabrizio, Claudia ^{[7
]}

Di Francia, Raffaele ^{[8
]}

Cacciamani, Andrea ^{[3
]}

Surico, Pier Luigi ^{[9
]}

D'Amato, Gerardo ^{[10
]}

Pisconti, Salvatore ^{[1
]}

机构：

[1] SG Moscati Hosp, Med Oncol, Taranto, Italy

[2] Univ Cattolica Sacro Cuore, CNR IASI, Rome, Italy

[3] IRCCS Fdn Bietti, Res Labs Ophthalmol, 6 Via Santo Stefano Rotondo, I-00184 Rome, Italy

[4] Aldo Moro Univ Bari, Oncogen Res Ctr, Dept Biomed Sci & Clin Oncol, Bari, Italy

[5] SG Moscati Hosp, Radiol, Taranto, Italy

[6] Luigi Vanvitelli Univ Campania, Dept Precis Med, Naples, Italy

[7] SG Moscati Hosp, Infect Dis Unit, Taranto, Italy

[8] Italian Assoc Pharmacogen & Mol Diagnost, Ancona, Italy

[9] F Miulli Hosp, Oncol & Hematol Dept, Acquaviva Delle Fonti, Italy

[10] A Gemelli Polyclin Fdn, Endocrine & Metab Surg, Rome, Italy

来源：

PHARMACOGENOMICS & PERSONALIZED MEDICINE | 2020年 / 13卷

关键词：

Covid-19; SARS-CoV2; drug effects; pharmacogenomics; pharmacogenetics; in silico; ADR; ACUTE LYMPHOBLASTIC-LEUKEMIA; RESPIRATORY SYNDROME; ATAZANAVIR PHARMACOKINETICS; ANTIRETROVIRAL REGIMENS; MULTIPLE-SCLEROSIS; CYTOKINE STORM; 2019; COVID-19; THERAPY; HYDROXYCHLOROQUINE; ASSOCIATION;

D O I：

10.2147/PGPM.S270069

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The latest developments in precision medicine allow the modulation of therapeutic approaches in different pathologies on the basis of the specific molecular characterization of the patient. This review of the literature coupled with in silico analysis was to provide a selected screening of interactions between single-nucleotide polymorphisms (SNPs) and drugs (repurposed, investigational, and biological agents) showing efficacy and toxicityin counteracting Covid-19 infection. In silico analysis of genetic variants related to each drug was performed on such databases as PharmGKB, Ensembl Genome Browser, www.drugs.com, and SNPedia, with an extensive literature review of papers (to May 10, 2020) on Covid-19 treatments using Medline, Embase, International Pharmaceutical Abstracts, PharmGKB, and Google Scholar. The clinical relevance of SNPs, known as both drug targets and markers, considering genetic variations with known drug responses, and the therapeutic consequences are discussed. In the context of clinical treatment of Covid-19, including infection prevention, control measures, and supportive care, this review highlights the importance of a personalized approach in the final selection of therapy, which is probably essential in the management of the Covid-19 pandemic.

引用

页码：463 / 484

页数：22

共 112 条

[31] Genetic variation associated with bortezomib-induced peripheral neuropathy [J].