Cyclodextrin pendant polymer as an efficient drug carrier for scutellarin

被引：24

作者：

Liao, Rongqiang ^{[1
]}

Liu, Ying ^{[1
]}

Lv, Pin ^{[2
,3
]}

Wu, Di ^{[1
]}

Xu, Meiling ^{[1
]}

Zheng, Xiaoyuan ^{[1
]}

机构：

[1] Chongqing Univ, Cent Hosp, Chongqing Emergency Med Ctr, Pharm Dept, Chongqing, Peoples R China

[2] Yunnan Acad Agr Sci, Ind Crop Res Inst, Kunming, Yunnan, Peoples R China

[3] Kunming Univ Sci & Technol, Fac Life Sci & Technol, Kunming, Yunnan, Peoples R China

来源：

DRUG DELIVERY | 2020年 / 27卷 / 01期

关键词：

Cyclodextrin; poly(ε -lysine); drug carrier; scutellarin;

D O I：

10.1080/10717544.2020.1856223

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel beta-cyclodextrin pendant polymer (epsilon-PL-CD), composed of poly(epsilon-lysine) (epsilon-PL) main chain and glycine-beta-cyclodextrin (Gly-CD) side chains, was prepared by a simple two-step procedure. The epsilon-PL-CD was investigated as a drug carrier of hydrophobic drug scutellarin (SCU). The characterization and complexation mode of the SCU:epsilon-PL-CD were researched in both solution and solid state by means of photoluminescence spectroscopy, H-1 and 2D NMR, X-Ray powder diffraction (XRPD), thermal gravimetric analysis, Particle size and Zeta potential. The solubility test indicated that the solubilizing ability of SCU:epsilon-PL-CD was significantly improved compared with SCU:beta-CD and free SCU. Besides, in vitro cell experiment, it was found that SCU:epsilon-PL-CD has a strong inhibitory effect on the growth and invasion of tumor cells. The present study provides useful information for epsilon-PL-CD as a drug carrier material.

引用

页码：1741 / 1749

页数：9

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