Complexity of the Association Between Psoriasis and Comorbidities

被引：89

作者：

Nijsten, Tamar ^{[1
]}

Wakkee, Marlies ^{[1
]}

机构：

[1] Erasmus MC, Dept Dermatol, NL-3015 CA Rotterdam, Netherlands

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2009年 / 129卷 / 07期

关键词：

RISK; LYMPHOMA;

D O I：

10.1038/jid.2009.55

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Multiple observational studies have recently demonstrated associations between psoriasis and several comorbidities-especially metabolic syndrome and cardiovascular disease, and now osteoporosis. It has been hypothesized that elevated levels of tumor necrosis factor-alpha are a biological explanation for the observed associations. In this commentary, we discuss the complexity of associations between psoriasis and comorbidities, possible residual confounding, the limitations of observational studies in proving causality, absolute versus relative risk differences, and the clinical relevance and possible clinical impact of "upgrading" psoriasis to a systemic disease.

引用

页码：1601 / 1603

页数：4

共 10 条

[1] Psoriasis and chronic obstructive pulmonary disease: a case-control study [J].

Dreiher, J. ;

Weitzman, D. ;

Shapiro, J. ;

Davidovici, B. ;

Cohen, A. D. .

BRITISH JOURNAL OF DERMATOLOGY, 2008, 159 (04) :956-960

[2] Psoriasis and Osteoporosis: A Sex-Specific Association? [J].

Dreiher, Jacob ;

Weitzman, Dahlia ;

Cohen, Arnon D. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2009, 129 (07) :1643-1649

[3] The risk of lymphoma in patients with psoriasis [J].

Gelfand, Joel M. ;

Shin, Daniel B. ;

Neimann, Andrea L. ;

Wang, Xingmei ;

Margolis, David J. ;

Troxel, Andrea B. .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2006, 126 (10) :2194-2201

[4] Risk of myocardial infarction in patients with psoriasis [J].

Gelfand, Joel M. ;

Neimann, Andrea L. ;

Shin, Daniel B. ;

Wang, Xingmei ;

Margolis, David J. ;

Troxel, Andrea B. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2006, 296 (14) :1735-1741

[5] Increased risk for cardiovascular mortality in psoriasis inpatients but not in outpatients [J].

Mallbris L. ;

Akre O. ;

Granath F. ;

Yin L. ;

Lindelöf B. ;

Ekbom A. ;

Ståhle-Bäckdahl M. .

European Journal of Epidemiology, 2004, 19 (3) :225-230

[6] Cigarette smoking, body mass index, and stressful life events as risk factors for psoriasis: Results from an Italian case-control study [J].

Naldi, L ;

Chatenoud, L ;

Linder, D ;

Fortina, AB ;

Peserico, A ;

Virgili, AR ;

Bruni, PL ;

Ingordo, V ;

Lo Scocco, G ;

Solaroli, C ;

Schena, D ;

Barba, A ;

Di Landro, A ;

Pezzarossa, E ;

Arcangeli, F ;

Gianni, C ;

Betti, R ;

Carli, P ;

Farris, A ;

Barabino, GF ;

La Vecchia, C .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2005, 125 (01) :61-67

[7] Obesity, waist circumference, weight change, and the risk of psoriasis in women - Nurses' health study II [J].

Setty, Arathi R. ;

Curhan, Gary ;

Choi, Hyon K. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (15) :1670-1675

[8] Lymphoma risk in psoriasis - Results of the PUVA follow-up study [J].

Stern, Robert S. .

ARCHIVES OF DERMATOLOGY, 2006, 142 (09) :1132-1135

[9] Psoriasis is common, carries a substantial burden even when not extensive, and is associated with widespread treatment dissatisfaction [J].

Stern, RS ;

Nijsten, T ;

Feldman, SR ;

Margolis, DJ ;

Rolstad, T .

JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS, 2004, 9 (02) :136-139

[10]

Wakkee M, 2008, J INVEST DERMATOL, V128, P2548

← 1 →