1α,25-dihydroxyvitamin D3 -: Not just a calciotropic hormone

被引：9
|
作者：
Kumar, R
机构：
[1] Mayo Clin & Mayo Fdn, Dept Med, Rochester, MN 55905 USA
[2] Mayo Clin & Mayo Fdn, Dept Biochem, Rochester, MN 55905 USA
[3] Mayo Clin & Mayo Fdn, Dept Mol Biol, Rochester, MN 55905 USA
来源：
NEPHRON | 2002年 / 91卷 / 04期
关键词：
vitamin D; 1; alpha; 25(OH)(2)D-3; growth factors; immune function;
D O I：
10.1159/000065015
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
1alpha,25-Dihydroxyvitamin D-3, the hormonal form of vitamin D-3, is widely appreciated to play a central role in calcium and phosphorous homeostasis. It is becoming increasingly clear, however, that the sterol also plays an important role in the regulation of cellular growth, central nervous system function, and immune responsiveness. In this review, I will highlight some of the mechanisms by which 1alpha,25-dihydroxyvitamin D-3 regulates cellular growth, alters central nervous system function, and immune function. Copyright (C) 2002 S. Karger AG, Basel.
引用
收藏
页码：576 / 581
页数：6
相关论文
共 50 条
  • [1] Nongenomic effects of 1α,25-dihydroxyvitamin D3
    Revelli, A
    Massobrio, M
    Tesarik, J
    TRENDS IN ENDOCRINOLOGY AND METABOLISM, 1998, 9 (10): : 419 - 427
  • [2] Efficient synthesis of novel oxime analogues of the hormone 1α, 25-dihydroxyvitamin D3
    Li, Hongliang
    Fang, Zhijie
    Dai, Huanran
    Zhang, Hengrui
    Liu, Yanan
    JOURNAL OF CHEMICAL RESEARCH, 2015, (06) : 368 - 372
  • [3] Primary Human Osteoblasts in Response to 25-Hydroxyvitamin D3, 1,25-Dihydroxyvitamin D3 and 24R, 25-Dihydroxyvitamin D3
    van der Meijden, Karen
    Lips, Paul
    van Driel, Marjolein
    Heijboer, Annemieke C.
    Schulten, Engelbert A. J. M.
    den Heijer, Martin
    Bravenboer, Nathalie
    PLOS ONE, 2014, 9 (10):
  • [4] Characterization of 3-epi-1α,25-dihydroxyvitamin D3 involved in 1α,25-dihydroxyvitamin D3 metabolic pathway in cultured cell lines
    Masuda, S
    Kamao, M
    Schroeder, NJ
    Makin, HLJ
    Jones, G
    Kremer, R
    Rhim, J
    Okano, T
    BIOLOGICAL & PHARMACEUTICAL BULLETIN, 2000, 23 (02) : 133 - 139
  • [5] Analogs of 1α′25-dihydroxyvitamin D3 as pluripotent Immunomodulators
    van Etten, E
    Decallonne, B
    Verlinden, L
    Verstuyf, A
    Bouillon, R
    Mathieu, C
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2003, 88 (02) : 223 - 226
  • [6] Analogs of 1α,25-Dihydroxyvitamin D3 in Clinical Use
    DeLuca, Hector F.
    Plum, Lori A.
    VITAMIN D HORMONE, 2016, 100 : 151 - 164
  • [7] 1,25-dihydroxyvitamin D3 -: a hormone with immunomodulatory properties
    Lemire, J
    ZEITSCHRIFT FUR RHEUMATOLOGIE, 2000, 59 : 24 - 27
  • [8] Expression of nephronectin is enhanced by 1α,25-dihydroxyvitamin D3
    Hiranuma, Katsuhiro
    Yamada, Atsushi
    Kurosawa, Tamaki
    Aizawa, Ryo
    Suzuki, Dai
    Saito, Yoshiro
    Nagahama, Ryo
    Ikehata, Mikiko
    Tsukasaki, Masayuki
    Morimura, Naoko
    Chikazu, Daichi
    Maki, Koutaro
    Shirota, Tatsuo
    Takami, Masamichi
    Yamamoto, Matsuo
    Iijima, Takehiko
    Kamijo, Ryutaro
    FEBS OPEN BIO, 2016, 6 (09): : 914 - 918
  • [9] The Use of 1α,25-Dihydroxyvitamin D3 as an Anticancer Agent
    Marcinkowska, Ewa
    Wallace, Graham R.
    Brown, Geoffrey
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2016, 17 (05)
  • [10] Comparison of 26,27-hexafluoro-1α,25-dihydroxyvitamin D3 and 1α,25-dihydroxyvitamin D3 on the resorption of bone explants ex vivo
    Miyahara, T
    Harada, M
    Kozakai, A
    Matsumoto, M
    Hashimoto, K
    Inoue, H
    Yoda, K
    Nakatsu, T
    Kajita, S
    Yamazaki, R
    Higuchi, S
    Kozuka, H
    Nemoto, N
    JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY, 1999, 45 (03) : 239 - 249
12345