Nivolumab-induced myocardial necrosis in a patient with lung cancer: A case report

被引：8
作者：
Sakai, Takashi [1 ,2 ]
Yahagi, Kazuyuki [3 ]
Hoshino, Tatsuhiro [1 ]
Yokota, Toshiya [1 ]
Tanabe, Kengo [3 ]
Mori, Masaya [4 ]
Ikeda, Shingo [1 ]
机构：
[1] Mitsui Mem Hosp, Div Thorac Surg, Chiyoda Ku, Kanda Izumicho 1, Tokyo 1018643, Japan
[2] Toho Univ, Grad Sch Med, Dept Surg, Div Chest Surg,Ota Ku, 6-11-1 Omorinishi, Tokyo 1438541, Japan
[3] Mitsui Mem Hosp, Div Cardiol, Chiyoda Ku, Kanda Izumicho 1, Tokyo 1018643, Japan
[4] Mitsui Mem Hosp, Div Pathol, Chiyoda Ku, Kanda Izumicho 1, Tokyo 1018643, Japan
来源：
RESPIRATORY MEDICINE CASE REPORTS | 2019年 / 27卷
关键词：
Nivolumab; Cardiotoxicity; Immune-related adverse events; DILATED CARDIOMYOPATHY; IMMUNE;
D O I：
10.1016/j.rmcr.2019.100839
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
A 74-year-old man with lung adenocarcinoma recurrence was admitted to our hospital because of dyspnea 7 days after receiving initial immunotherapy with nivolumab. Electrocardiography revealed ST-segment elevation in V1-6 and echocardiography showed a markedly reduced left ventricular ejection fraction of 9% and akinesis of the anteroseptal wall and apex. He died from acute heart failure 3 days after admission. Microscopically, multiple small foci of myocardial necrosis with few inflammatory cells were scattered in both ventricles. Obstruction of the coronary artery was not identified. We believed that the cause of death was acute heart failure possibly due to nivolumab-induced myocardial necrosis.
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