Immunological risks of adult T-cell leukemia at primary HTLV-I infection

被引：35

作者：

Kannagi, M ^{[1
]}

Ohashi, T ^{[1
]}

Harashima, N ^{[1
]}

Hanabuchi, S ^{[1
]}

Hasegawa, A ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Tokyo 11388519, Japan

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 07期

关键词：

D O I：

10.1016/j.tim.2004.05.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A small percentage of human T-cell leukemia virus type-I (HTLV-I)-infected individuals develop adult T-cell leukemia (ATL). In animal experiments, inoculation of HTLV-1 via the oral route, which is the main route of mother-to-child viral transmission in humans as a result of breastfeeding, induced host HTLV-1-specific T-cell unresponsiveness and resulted in increased viral load. This strongly suggested that the known epidemiological risk factors for ATL (i.e. vertical HTLV-1 infection and elevated viral load) are linked by an insufficient HTLV-1-specific T-cell response. Recent findings on the antitumor effects of Tax-targeted vaccination in rats and the reactivation of Tax-specific T cells in ATL patients as a result of hematopoietic stem cell transplantation imply promising immunological approaches for the prophylaxis and therapy of ATL.

引用

页码：346 / 352

页数：7

共 74 条

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