Immunological risks of adult T-cell leukemia at primary HTLV-I infection

被引：35

作者：

Kannagi, M ^{[1
]}

Ohashi, T ^{[1
]}

Harashima, N ^{[1
]}

Hanabuchi, S ^{[1
]}

Hasegawa, A ^{[1
]}

机构：

[1] Tokyo Med & Dent Univ, Div Med Res, Dept Immunotherapeut, Tokyo 11388519, Japan

来源：

TRENDS IN MICROBIOLOGY | 2004年 / 12卷 / 07期

关键词：

D O I：

10.1016/j.tim.2004.05.005

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A small percentage of human T-cell leukemia virus type-I (HTLV-I)-infected individuals develop adult T-cell leukemia (ATL). In animal experiments, inoculation of HTLV-1 via the oral route, which is the main route of mother-to-child viral transmission in humans as a result of breastfeeding, induced host HTLV-1-specific T-cell unresponsiveness and resulted in increased viral load. This strongly suggested that the known epidemiological risk factors for ATL (i.e. vertical HTLV-1 infection and elevated viral load) are linked by an insufficient HTLV-1-specific T-cell response. Recent findings on the antitumor effects of Tax-targeted vaccination in rats and the reactivation of Tax-specific T cells in ATL patients as a result of hematopoietic stem cell transplantation imply promising immunological approaches for the prophylaxis and therapy of ATL.

引用

页码：346 / 352

页数：7

共 74 条

[1] Loss of the ex vivo but not the reinducible CD8+ T-cell response to Tax in human T-cell leukemia virus type 1-infected patients with adult T-cell leukemia/lymphoma [J].

Arnulf, B ;

Thorel, M ;

Poirot, Y ;

Tamouza, R ;

Boulanger, E ;

Jaccard, A ;

Oksenhendler, E ;

Hermine, O ;

Pique, C .

LEUKEMIA, 2004, 18 (01) :126-132

[2] The immune response to HTLV-1 [J].

Bangham, CRM .

CURRENT OPINION IN IMMUNOLOGY, 2000, 12 (04) :397-402

[3] SEQUENCE VARIANTS OF HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-I FROM PATIENTS WITH TROPICAL SPASTIC PARAPARESIS AND ADULT T-CELL LEUKEMIA DO NOT DISTINGUISH NEUROLOGICAL FROM LEUKEMIC ISOLATES [J].

DAENKE, S ;

NIGHTINGALE, S ;

CRUICKSHANK, JK ;

BANGHAM, CRM .

JOURNAL OF VIROLOGY, 1990, 64 (03) :1278-1282

[4] HIGH HUMAN T-CELL LYMPHOTROPIC VIRUS TYPE-1 (HTLV-1) SPECIFIC PRECURSOR CYTOTOXIC T-LYMPHOCYTE FREQUENCIES IN PATIENTS WITH HTLV-1 ASSOCIATED NEUROLOGICAL DISEASE [J].

ELOVAARA, I ;

KOENIG, S ;

BREWAH, AY ;

WOODS, RM ;

LEHKY, T ;

JACOBSON, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1567-1573

[5] Mouse model for the equilibration interaction between the host immune system and human T-cell leukemia virus type 1 gene expression [J].

Furuta, RA ;

Sugiura, K ;

Kawakita, S ;

Inada, T ;

Ikehara, S ;

Matsuda, T ;

Fujisawa, J .

JOURNAL OF VIROLOGY, 2002, 76 (06) :2703-2713

[6]

GESSAIN A, 1985, LANCET, V2, P407

[7] Regression of human T-cell leukemia virus type I (HTLV-I)-associated lymphomas in a rat model: Peptide-induced T-cell immunity [J].

Hanabuchi, S ;

Ohashi, T ;

Koya, Y ;

Kato, H ;

Hasegawa, A ;

Takemura, F ;

Masuda, T ;

Kannagi, M .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2001, 93 (23) :1775-1783

[8] Fratricide among CD8+ T lymphocytes naturally infected with human T cell lymphotropic virus type I [J].

Hanon, E ;

Stinchcombe, JC ;

Saito, M ;

Asquith, BE ;

Taylor, GP ;

Tanaka, Y ;

Weber, JN ;

Griffiths, GM ;

Bangham, CRM .

IMMUNITY, 2000, 13 (05) :657-664

[9] Graft-versus-tax response in adult T-cell leukemia patients after hematopoietic stem cell transplantation [J].

Harashima, N ;

Kurihara, K ;

Utsunomiya, A ;

Tanosaki, R ;

Hanabuchi, S ;

Masuda, M ;

Ohashi, T ;

Fukui, F ;

Hasegawa, A ;

Masuda, T ;

Takaue, Y ;

Okamura, J ;

Kannagi, M .

CANCER RESEARCH, 2004, 64 (01) :391-399

[10] Expansion of human T-cell leukemia virus type 1 (HTLV-1) reservoir in orally infected rats: Inverse correlation with HTLV-1-specific cellular immune response [J].

Hasegawa, A ;

Ohashi, T ;

Hanabuchi, S ;

Kato, H ;

Takemura, F ;

Masuda, T ;

Kannagi, M .

JOURNAL OF VIROLOGY, 2003, 77 (05) :2956-2963

← 1 2 3 4 5 6 7 8 →