[4+3]-Cycloaddition of aza-o-quinone methides and azomethine imines to make 1,2,4-triazepines

被引：16

作者：

Meng, Zhongrong ^{[2
]}

Yang, Weiran ^{[1
]}

Zheng, Jing ^{[1
]}

机构：

[1] Nanchang Univ, Sch Resources Environm & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China

[2] Nanchang Univ, Coll Chem, Nanchang 330031, Jiangxi, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 27期

关键词：

4+3]-Cycloaddition; Triazepine; Aza-Michael/aminalization; Heterocycles; CATALYZED 4+3 CYCLOADDITION; PRIVILEGED STRUCTURES; KINETIC RESOLUTION; ANNULATIONS; INDOLES; CASCADE; ACCESS;

D O I：

10.1016/j.tetlet.2019.05.038

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this study, an unprecedented [4 + 3] annulation of aza-ortho-quinone methides with azomethine imines was achieved under mild conditions. Annulation via the aza-Michael/aminalization sequence served as a useful method to synthesize biological heterocycles in good-to-excellent yields. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：1758 / 1762

页数：5

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