From HPV-positive towards HPV-driven oropharyngeal squamous cell carcinomas

被引：68

作者：

Boscolo-Rizzo, Paolo ^{[1
]}

Pawlita, Michael ^{[2
]}

Holzinger, Dana ^{[2
]}

机构：

[1] Univ Padua, Reg Ctr Head & Neck Canc, Dept Neurosci, Ple Osped 1, I-31100 Treviso, Italy

[2] German Canc Res Ctr, Res Program Infect & Canc, Div Mol Diagnost Oncogen Infect, F020, Heidelberg, Germany

来源：

CANCER TREATMENT REVIEWS | 2016年 / 42卷

关键词：

E6; mRNA; Head and neck squamous cell carcinoma; Human papillomavirus; HPV DNA; In situ hybridization; Oropharyngeal carcinoma; p16(INK4a) immunohistochemistry; Serology; HUMAN-PAPILLOMAVIRUS HPV; TREATMENT DE-ESCALATION; HIGH VIRAL LOAD; NECK-CANCER; HUMAN-PAPILLOMAVIRUS-16; DNA; RETINOBLASTOMA PROTEIN; TONSILLAR CARCINOMAS; CRITICAL-ISSUES; HEAD; EXPRESSION;

D O I：

10.1016/j.ctrv.2015.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The incidence of HPV-positive oropharyngeal squamous cell carcinoma (OPSCC), which is both biologically and clinically distinct from tobacco- and alcohol-related OPSCC, is dramatically increasing. The finding that individuals with HPV-positive local/regionally advanced OPSCC have a significantly better prognosis than their negative counterparts have led to efforts to de-escalate treatment in those patients to avoid serious side effects and to improve their long-term quality of life, while maintaining treatment efficacy. Identifying diagnostic tests that are able to distinguish cancers etiologically associated with HPV is thus becoming a pressing challenge for researchers. The purpose of this review is to provide an overview of the diagnostic tools presently available to evaluate HPV status in patients with OPSCC and, in particular, to discuss their strengths and weaknesses in identifying those infections that are the real driving force in the oropharyngeal carcinogenesis process. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：24 / 29

页数：6

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