pH Sensitive Pluronic Acid/Agarose-Hydrogels as Controlled Drug Delivery Carriers: Design, Characterization and Toxicity Evaluation

被引：28

作者：

Aslam, Mariam ^{[1
]}

Barkat, Kashif ^{[1
]}

Malik, Nadia Shamshad ^{[2
]}

Alqahtani, Mohammed S. ^{[3
]}

Anjum, Irfan ^{[1
]}

Khalid, Ikrima ^{[4
]}

Tulain, Ume Ruqia ^{[5
]}

Gohar, Nitasha ^{[2
]}

Zafar, Hajra ^{[6
]}

Paiva-Santos, Ana Claudia ^{[7
,8
]}

Raza, Faisal ^{[2
,6
]}

机构：

[1] Univ Lahore, Fac Pharm, Lahore 54000, Pakistan

[2] Capital Univ Sci & Technol CUST, Fac Pharm, Islamabad 44000, Pakistan

[3] King Saud Univ, Coll Pharm, Dept Pharmaceut, Riyadh 11451, Saudi Arabia

[4] GC Univ, Fac Pharmaceut Sci, Faisalabad 38000, Pakistan

[5] Univ Sargodha, Fac Pharm, Sargodha 40100, Pakistan

[6] Shanghai Jiao Tong Univ, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China

[7] Univ Coimbra, Fac Pharm, Dept Pharmaceut Technol, P-3000548 Coimbra, Portugal

[8] Univ Coimbra, Fac Pharm, Grp Pharmaceut Technol, REQUIMTE LAQV, P-3000548 Coimbra, Portugal

来源：

PHARMACEUTICS | 2022年 / 14卷 / 06期

关键词：

agarose; pluronic acid; methacrylic acid; pH sensitive behavior; acute toxicity; IN-VITRO; POLYMER NETWORK; ACID HYDROGELS; ORAL DELIVERY; RELEASE; CYTARABINE; SYSTEM; OPTIMIZATION; FABRICATION; THERAPY;

D O I：

10.3390/pharmaceutics14061218

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The objective of this study was to fabricate and evaluate a pH sensitive cross-linked polymeric network through the free radical polymerization technique for the model drug, cyclophosphamide, used in the treatment of non-Hodgkin's lymphoma. The Hydrogels were prepared using a polymeric blend of agarose, Pluronic acid, glutaraldehyde, and methacrylic acid. The prepared hydrogels were characterized for drug loading (%), swelling pattern, release behavior, the ingredient's compatibility, structural evaluation, thermal integrity, and toxicity evaluation in rabbits. The new polymer formation was evident from FTIR findings. The percentage loaded into the hydrogels was in the range of 58.65-75.32%. The developed hydrogels showed significant differences in swelling dynamics and drug release behavior in simulated intestinal fluid (SIF) when compared with simulated gastric fluid (SGF). The drug release was persistent and performed in a controlled manner for up to 24 h. A toxicity study was conducted on white albino rabbits. The developed hydrogels did not show any signs of ocular, skin, or oral toxicity; therefore, these hydrogels can be regarded as safe and potential carriers for controlled drug delivery in biomedical applications.

引用

页数：20

共 82 条

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