Despite the progress made in the clinical management of sepsis, sepsis morbidity and mortality rates remain high. The inflammatory pathogenesis and organ injury leading to death from sepsis are not fully understood for vital organs, especially the liver. Only recently has the role of the liver in sepsis begun to be revealed. Pre-existing liver dysfunction is a risk factor for the progression of infection to sepsis. Liver dysfunction after sepsis is an independent risk factor for multiple organ dysfunction and sepsis-induced death. The liver works as a lymphoid organ in response to sepsis. Acting as a double-edged sword in sepsis, the liver-mediated immune response is responsible for clearing bacteria and toxins but also causes inflammation, immunosuppression, and organ damage. Attenuating liver injury and restoring liver function lowers morbidity and mortality rates in patients with sepsis. This review summarizes the central role of liver in the host immune response to sepsis and in clinical outcomes.
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Guo, Yongjing
Guo, Wanxu
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机构:
Second Hosp Jilin Univ, Dept Neonate, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Guo, Wanxu
Chen, Huimin
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h-index: 0
机构:
Second Hosp Jilin Univ, Dept Neonate, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Chen, Huimin
Sun, Jian
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h-index: 0
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Sun, Jian
Yin, Yongjie
论文数: 0引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Yin, Yongjie
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
2025,
15
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Vrsaljko, Nina
Matotek, Leona Radmanic
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h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Dept Immunol & Mol Diagnost, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Matotek, Leona Radmanic
Zidovec-Lepej, Snjezana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Dept Immunol & Mol Diagnost, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Zidovec-Lepej, Snjezana
Vince, Adriana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljev, Dept Viral Hepatitis, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Vince, Adriana
Papic, Neven
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljev, Dept Viral Hepatitis, Zagreb 10000, Croatia
Univ Zagreb, Sch Med, Dept Infect Dis, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi ArabiaHelwan Univ, Fac Sci, Dept Chem, Mol Biotechnol Program, Cairo, Egypt
Abdel-Gaber, Rewaida
Alquraishi, Mohammed I.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, Riyadh, Saudi ArabiaHelwan Univ, Fac Sci, Dept Chem, Mol Biotechnol Program, Cairo, Egypt
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
Aki, Toshihiko
Unuma, Kana
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
Unuma, Kana
Uemura, Koichi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Chung, Ki Wung
Kim, Kyung Mok
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h-index: 0
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Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Kim, Kyung Mok
Choi, Yeon Ja
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h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Choi, Yeon Ja
An, Hye Jin
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h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
An, Hye Jin
Lee, Bonggi
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
KIOM, Korean Med KM Applicat Ctr, Daegu, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Bonggi
Kim, Dae Hyun
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Kim, Dae Hyun
Lee, Eun Kyeong
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Eun Kyeong
Im, Eunok
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Im, Eunok
Lee, Jaewon
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Jaewon
Im, Dong Soon
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Im, Dong Soon
Yu, Byung Pal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USAPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Yu, Byung Pal
Chung, Hae Young
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Liu, Yanting
Tan, Sichuang
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Tan, Sichuang
Wu, Yongbin
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Wu, Yongbin
Tan, Sipin
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Guo, Yongjing
Guo, Wanxu
论文数: 0引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Neonate, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Guo, Wanxu
Chen, Huimin
论文数: 0引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Neonate, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Chen, Huimin
Sun, Jian
论文数: 0引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Sun, Jian
Yin, Yongjie
论文数: 0引用数: 0
h-index: 0
机构:
Second Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R ChinaSecond Hosp Jilin Univ, Dept Emergency & Crit Care, Changchun, Peoples R China
Yin, Yongjie
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY,
2025,
15
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Vrsaljko, Nina
Matotek, Leona Radmanic
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Dept Immunol & Mol Diagnost, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Matotek, Leona Radmanic
Zidovec-Lepej, Snjezana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljevic, Dept Immunol & Mol Diagnost, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Zidovec-Lepej, Snjezana
Vince, Adriana
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljev, Dept Viral Hepatitis, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
Vince, Adriana
Papic, Neven
论文数: 0引用数: 0
h-index: 0
机构:
Univ Hosp Infect Dis Dr Fran Mihaljev, Dept Viral Hepatitis, Zagreb 10000, Croatia
Univ Zagreb, Sch Med, Dept Infect Dis, Zagreb 10000, CroatiaUniv Hosp Infect Dis Dr Fran Mihaljevic, Emergency Infect Dis Dept, Zagreb 10000, Croatia
机构:
King Saud Univ, Coll Sci, Dept Zool, Riyadh, Saudi ArabiaHelwan Univ, Fac Sci, Dept Chem, Mol Biotechnol Program, Cairo, Egypt
Abdel-Gaber, Rewaida
Alquraishi, Mohammed I.
论文数: 0引用数: 0
h-index: 0
机构:
King Saud Univ, Coll Appl Med Sci, Dept Community Hlth Sci, Riyadh, Saudi ArabiaHelwan Univ, Fac Sci, Dept Chem, Mol Biotechnol Program, Cairo, Egypt
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
Aki, Toshihiko
Unuma, Kana
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
Unuma, Kana
Uemura, Koichi
论文数: 0引用数: 0
h-index: 0
机构:
Tokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, JapanTokyo Med & Dent Univ, Grad Sch Med & Dent Sci, Dept Forens Med, Tokyo 1138519, Japan
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Chung, Ki Wung
Kim, Kyung Mok
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Kim, Kyung Mok
Choi, Yeon Ja
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Choi, Yeon Ja
An, Hye Jin
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
An, Hye Jin
Lee, Bonggi
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
KIOM, Korean Med KM Applicat Ctr, Daegu, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Bonggi
Kim, Dae Hyun
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Kim, Dae Hyun
Lee, Eun Kyeong
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Eun Kyeong
Im, Eunok
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Im, Eunok
Lee, Jaewon
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Lee, Jaewon
Im, Dong Soon
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Im, Dong Soon
Yu, Byung Pal
论文数: 0引用数: 0
h-index: 0
机构:
Univ Texas Hlth Sci Ctr San Antonio, Dept Physiol, San Antonio, TX 78229 USAPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
Yu, Byung Pal
Chung, Hae Young
论文数: 0引用数: 0
h-index: 0
机构:
Pusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South KoreaPusan Natl Univ, Coll Pharm, Mol Inflammat Res Ctr Aging Intervent MRCA, Busan 609735, South Korea
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Liu, Yanting
Tan, Sichuang
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Hosp 2, Dept Thorac Surg, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Tan, Sichuang
Wu, Yongbin
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Wu, Yongbin
Tan, Sipin
论文数: 0引用数: 0
h-index: 0
机构:
Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China
Sepsis Translat Med Key Lab Hunan Prov, Changsha, Peoples R ChinaCent South Univ, Xiangya Sch Med, Dept Pathophysiol, Changsha 410008, Peoples R China