Coagulopathies in novel coronavirus (SARS-CoV-2) pandemic: Emerging evidence for hematologists

被引:4
作者
Al-Subaie, Abeer M. [1 ]
机构
[1] Imam AbdulRahman Bin Faisal Univ, Coll Appl Med Sci, Dept Clin Lab Sci, POB 1982, Dammam 31441, Saudi Arabia
关键词
COVID-19; SARS-CoV-2; Thrombosis; Anticoagulant therapy; Disseminated intravascular coagulation (DIC); EPIDEMIOLOGY; CYTOKINES; COVID-19; HEPARIN;
D O I
10.1016/j.sjbs.2020.11.006
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The coronavirus disease (COVID-19), which is also known as acute respiratory syndrome coronavirus-2 (SARS-CoV2) is a transmissible disease, has phenotypes varying from asymptomatic to Acute Respiratory Distress Syndrome (ARDS) or multiple organ dysfunction syndrome (MODS) and ultimately death in certain cases. Coagulation disorders are being frequently reported amongst these patients and the pathogenesis is still not completely understood. Proposed mechanisms for these coagulopathies com-prise a hypercoagulable state with microand/or macro-thrombosis in the vessels. A number of changes have been reported or proposed in circulating prothrombotic factors in COVID-19 patients and includes elevation in both factor VIII and fibrinogen, circulating prothrombotic microparticles and hyperviscosity. The COVID-19 patients are showing varied coagulopathies and are at high risk for venous thromboembolism (VTE) which demands an early intervention. This paper reviews the evolving data regarding the evaluation and managing of coagulopathies in patients with COVID-19. (C) 2020 The Author. Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license.
引用
收藏
页码:956 / 961
页数:6
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