Synergistic effect of quercetin and quinic acid by alleviating structural degeneration in the liver, kidney and pancreas tissues of STZ-induced diabetic rats: A mechanistic study

被引：85

作者：

Arya, Aditya ^{[1
]}

Al-Obaidi, Mazen M. Jamil ^{[2
]}

Shahid, Nayiar ^{[1
]}

Bin Noordin, Mohamed Ibrahim ^{[1
]}

Looi, Chung Yeng ^{[3
]}

Wong, Won Fen ^{[4
]}

Khaing, Si Lay ^{[5
]}

Mustafa, Mohd Rais ^{[3
]}

机构：

[1] Univ Malaya, Fac Med, Dept Pharm, Kuala Lumpur 50603, Malaysia

[2] Univ Technol MAR UiTM, Fac Dent, Ctr Studies Periodontol, Shah Alam, Selangor, Malaysia

[3] Univ Malaya, Fac Med, Dept Pharmacol, Kuala Lumpur 50603, Malaysia

[4] Univ Malaya, Fac Med, Dept Med Microbiol, Kuala Lumpur 50603, Malaysia

[5] Univ Malaya, Fac Med, Dept Obstet & Gynaecol, Kuala Lumpur 50603, Malaysia

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2014年 / 71卷

关键词：

Synergistic effect; Quercetin; Quinic acid; Streptozotocin; Diabetes mellitus; PRO-INFLAMMATORY CYTOKINES; KAPPA-B ACTIVATION; OXIDATIVE STRESS; FLAVONOID ANTIOXIDANT; METHANOLIC FRACTION; UP-REGULATION; CELL-DEATH; GLUCOSE; EXPRESSION; BCL-2;

D O I：

10.1016/j.fct.2014.06.010

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

The aim of this study was to investigate the synergistic effects of quercetin (QE) and quinic acid (QA) on a STZ-induced diabetic rat model to determine their potential role in alleviating diabetes and its associated complications. In our study design, diabetic rats were treated with single and combined doses of QE and QA for 45 days to analyse their effects on liver, kidney and pancreas tissues. The study result showed that QE and QA treated groups down-regulated hyperglycaemia and oxidative stress by up-regulating insulin and C-peptide levels. Moreover, histological observations of the liver, kidney and pancreas of diabetic rats treated with single and combined doses of QE and QA showed a significant improvement in the structural degeneration. Interestingly, the combination dose of QE and QA (50 mg/kg) exhibited maximum inhibition of the pro-apoptotic protein Bax expression and demonstrate enhancement of the anti-apoptotic protein BcI-2 expression in the kidney tissues, suggesting a protective role in the kidneys of diabetic rats. Taken together, these results indicates the synergistic effects of QE and QA in ameliorating hyperglycaemia, hyperlipidemia and insulin resistance in diabetic rats and therefore, open a new window of research on the combinatorial therapy of flavonoids. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：183 / 196

页数：14

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