The IκB kinase complex in NF-κB regulation and beyond

被引：483

作者：

Hinz, Michael ^{[1
]}

Scheidereit, Claus ^{[1
]}

机构：

[1] Max Delbruck Ctr Mol Med, Berlin, Germany

来源：

EMBO REPORTS | 2014年 / 15卷 / 01期

关键词：

cancer; development; differentiation; inflammation; immunity; NEGATIVE FEEDBACK LOOP; ANHIDROTIC ECTODERMAL DYSPLASIA; GAMMA-DEPENDENT PHOSPHORYLATION; SQUAMOUS-CELL CARCINOMAS; TUMOR-INITIATING CELLS; NECROSIS-FACTOR-ALPHA; NUCLEAR IKK ACTIVITY; UBIQUITIN CHAINS; CRYSTAL-STRUCTURE; GENE-EXPRESSION;

D O I：

10.1002/embr.201337983

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The I kappa B kinase (IKK) complex is the signal integration hub for NF-kappa B activation. Composed of two serine-threonine kinases (IKK alpha and IKK beta) and the regulatory subunit NEMO (also known as IKK gamma), the IKK complex integrates signals from all NF-kappa B activating stimuli to catalyze the phosphorylation of various I kappa B and NF-kappa B proteins, as well as of other substrates. Since the discovery of the IKK complex components about 15 years ago, tremendous progress has been made in the understanding of the IKK architecture and its integration into signaling networks. In addition to the control of NF-kappa B, IKK subunits mediate the crosstalk with other pathways, thereby extending the complexity of their biological function. This review summarizes recent advances in IKK biology and focuses on emerging aspects of IKK structure, regulation and function.

引用

收藏

页码：46 / 61

页数：16

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