Regioselective reaction: Synthesis of novel Mannich bases derived from 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles and their antimicrobial properties

被引：0

作者：

Lingappa, B. ^{[1
,2
]}

Girisha, K. S. ^{[1
]}

Kalluraya, Balakrishna ^{[1
]}

Rai, N. Satheesh ^{[1
]}

Kumari, Nalilu Suchetha ^{[3
]}

机构：

[1] Mangalore Univ, Dept Studies Chem, Mangalagangothri 574199, Karnataka, India

[2] Strides Res & Specialty Chem Ltd, Mangalore 575011, India

[3] Justice KS Hegde Acad, Dept Biochem, Deralakatte, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2008年 / 47卷 / 12期

关键词：

1,2,4-Triazoles; pyrimidines; Schiff bases; Mannich bases;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new series of 3-(4,6-disubstituted-2-thiomethylpyrimidyl)-4-amino-5-mercapto-1,2-4-triazoles have been synthesized. These triazoles on reaction with aldehydes in the presence of acid catalyst forms Schiff's bases. These Schiff's bases can exist both in the thiol as well as in the thione tautomeric form. However when these compounds are subjected to Mannich reaction, N-Mannich bases 7a-f are obtained rather than the S-Mannich bases. The structures of the new compounds have been confirmed by spectral and analytical data. Few of these Mannish bases have been evaluated for their possible antifungal and antibacterial activity. Most of the tested compounds show significant antifungal and antibacterial activity.

引用

页码：1858 / 1864

页数：7

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