A metagenomic analysis of the modulatory effect of Cyclocarya paliurus flavonoids on the intestinal microbiome in a high-fat diet-induced obesity mouse model

被引：43

作者：

Cheng, Lu ^{[1
]}

Chen, Yuhui ^{[2
]}

Zhang, Xin ^{[2
]}

Zheng, Xiaojie ^{[3
]}

Cao, Jinxuan ^{[2
]}

Wu, Zufang ^{[2
]}

Qin, Wenyan ^{[4
]}

Cheng, Kejun ^{[5
]}

机构：

[1] Rutgers State Univ, Dept Food Sci, New Brunswick, NJ USA

[2] Ningbo Univ, Dept Food Sci & Engn, Ningbo 315211, Zhejiang, Peoples R China

[3] Wenzhou Vocat Coll Sci & Technol, Dept Agr & Biotechnol, Wenzhou, Peoples R China

[4] Yinzhou Dist Second Hosp Ningbo City, Ningbo, Zhejiang, Peoples R China

[5] Lishui Univ, Coll Ecol, Lishui, Peoples R China

来源：

JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE | 2019年 / 99卷 / 08期

关键词：

Cyclocarya paliurus flavonoids; intestinal microbiome; metagenomics; modulatory effect; obesity; FERMENTATION IN-VITRO; GUT MICROBIOTA; POLYPHENOLS; METABOLISM; QUERCETIN; DYSBIOSIS; BACTERIA;

D O I：

10.1002/jsfa.9622

中图分类号：

S [农业科学];

学科分类号：

09 ;

摘要：

BACKGROUND As a result of a low bioavailability, the majority of Cyclocarya paliurus flavonoids (CPF) remain in the large intestine where they accumulate to exert a modulatory effect on the intestinal micro-ecology. Therefore, the present study investigated the modulatory effect of CPF on intestinal microbiota. RESULTS CPF dramatically ameliorated the obesity-induced gut dysbiosis. A significant decrease (P < 0.05) was observed in the ratio of Firmicutes/Bacteroidetes after CPF treatment for 8 weeks. Moreover, Kyoto Encyclopedia of Genes and Genomes pathways of biosynthesis of amino acids, the two-component system and ATP-binding cassette transporters enriched the most differentially expressed genes after CPF intervention. CONCLUSION The results of the present study indicate that CPF might have prebiotic-like activity and could be used as a functional food component with potential therapeutic utility to prevent obesity-related metabolic disorders by manipulating the gut flora and affecting certain metabolic pathways, thus contributing to the improvement of human health. (c) 2019 Society of Chemical Industry

引用

页码：3967 / 3975

页数：9

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