Insulin inhibition of platelet-endothelial interaction is mediated by insulin effects on endothelial cells without direct effects on platelets: a rebuttal

被引：3
作者：
Akkerman, J. W. N. [1 ]
Gerrits, A. J. [1 ]
Ferreira, I. A. [2 ]
Heemskerk, J. W. M. [3 ]
机构：
[1] Univ Med Ctr Utrecht, Dept Clin Chem & Haematol, Utrecht, Netherlands
[2] Isala Clin, Dept Cardiol, Zwolle, Netherlands
[3] Univ Maastricht, Maastricht, Netherlands
来源：
JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2009年 / 7卷 / 02期
关键词：
TYPE-2; DIABETES-MELLITUS; ACTIVATION; PROTEIN; ADP; AGGREGATION; MECHANISMS; RECEPTORS; SECRETION; THERAPY; P2Y(1);
D O I：
10.1111/j.1538-7836.2008.03239.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：369 / 371
页数：3
相关论文
共 19 条
[1]   P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries [J].
André, P ;
Delaney, SM ;
LaRocca, T ;
Vincent, D ;
DeGuzman, F ;
Jurek, M ;
Koller, B ;
Phillips, DR ;
Conley, PB .
JOURNAL OF CLINICAL INVESTIGATION, 2003, 112 (03) :398-406
[2]   Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease - Results of the Optimizing antiPlatelet Therapy In diabetes MellitUS (OPTIMUS) study [J].
Angiolillo, Dominick J. ;
Shoemaker, Steven B. ;
Desai, Bhaloo ;
Yuan, Hang ;
Charlton, Ronald K. ;
Bernardo, Esther ;
Zenni, Martin M. ;
Guzman, Luis A. ;
Bass, Theodore A. ;
Costa, Marco A. .
CIRCULATION, 2007, 115 (06) :708-716
[3]   Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatment [J].
Angiolillo, Dominick J. ;
Bernardo, Esther ;
Ramirez, Celia ;
Costa, Marco A. ;
Sabate, Manel ;
Jimenez-Quevedo, Pilar ;
Hernandez, Rosana ;
Moreno, Raul ;
Escaned, Javier ;
Alfonso, Fernando ;
Banuelos, Camino ;
Bass, Theodore A. ;
Macaya, Carlos ;
Fernandez-Ortiz, Antonio .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2006, 48 (02) :298-304
[4]  
Baurand A, 2000, THROMB HAEMOSTASIS, V84, P484
[5]   ADP IS A POTENT INHIBITOR OF HUMAN-PLATELET PLASMA-MEMBRANE ADENYLATE-CYCLASE [J].
COOPER, DMF ;
RODBELL, M .
NATURE, 1979, 282 (5738) :517-518
[6]   Platelet inhibition by insulin is absent in type 2 diabetes mellitus [J].
Ferreira, IA ;
Mocking, AIM ;
Feijge, MAH ;
Gorter, G ;
van Haeften, TW ;
Heemskerk, JWM ;
Akkerman, JWN .
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2006, 26 (02) :417-422
[7]   Glucose uptake via glucose transporter 3 by human platelets is regulated by protein kinase B [J].
Ferreira, IA ;
Mocking, AIM ;
Urbanus, RT ;
Varlack, S ;
Wnuk, M ;
Akkerman, JWN .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (38) :32625-32633
[8]   IRS-1 mediates inhibition of Ca2+ mobilization by insulin via the inhibitory G-protein Gi [J].
Ferreira, IA ;
Eybrechts, KL ;
Mocking, AIM ;
Kroner, C ;
Akkerman, JWN .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2004, 279 (05) :3254-3264
[9]   The genetic basis of type 2 diabetes mellitus: Impaired insulin secretion versus impaired insulin sensitivity [J].
Gerich, JE .
ENDOCRINE REVIEWS, 1998, 19 (04) :491-503
[10]   P2Y1 and P2Y12 receptors for ADP desensitize by distinct kinase-dependent mechanisms [J].
Hardy, AR ;
Conley, PB ;
Luo, JS ;
Benovic, JL ;
Poole, AW ;
Mundell, SJ .
BLOOD, 2005, 105 (09) :3552-3560
12