Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades

被引：334

作者：

Togao, Osamu ^{[1
,2
]}

Yoshiura, Takashi ^{[2
]}

Keupp, Jochen ^{[3
]}

Hiwatashi, Akio ^{[2
]}

Yamashita, Koji ^{[2
]}

Kikuchi, Kazufumi ^{[2
]}

Suzuki, Yuriko ^{[4
]}

Suzuki, Satoshi O. ^{[5
]}

Iwaki, Toru ^{[5
]}

Hata, Nobuhiro ^{[6
]}

Mizoguchi, Masahiro ^{[6
]}

Yoshimoto, Koji ^{[6
]}

Sagiyama, Koji ^{[7
]}

Takahashi, Masaya ^{[7
]}

Honda, Hiroshi ^{[2
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Mol Imaging & Diag, Fukuoka 812, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Clin Radiol, Fukuoka 812, Japan

[3] Philips Res, Hamburg, Germany

[4] Philips Elect Japan, Tokyo, Japan

[5] Kyushu Univ, Grad Sch Med Sci, Dept Neuropathol, Fukuoka 812, Japan

[6] Kyushu Univ, Grad Sch Med Sci, Dept Neurosurg, Fukuoka 812, Japan

[7] UT Southwestern Med Ctr, Adv Imaging Res Ctr, Dallas, TX USA

来源：

NEURO-ONCOLOGY | 2014年 / 16卷 / 03期

关键词：

amide proton transfer (APT) imaging; chemical exchange saturation transfer (CEST); glioma; P-31 MR SPECTROSCOPY; BLOOD-VOLUME MAPS; BRAIN-TUMORS; SATURATION-TRANSFER; CONTRAST; CLASSIFICATION; GLIOBLASTOMA; COEFFICIENT; PEPTIDES; PROTEINS;

D O I：

10.1093/neuonc/not158

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background. Amide proton transfer (APT) imaging is a novel molecular MRI technique to detect endogenous mobile proteins and peptides through chemical exchange saturation transfer. We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas. Methods. Thirty-six consecutive patients with histopathologically proven diffuse glioma (48.1 +/- 14.7 y old, 16 males and 20 females) were included in the study. APT MRI was conducted on a 3T clinical scanner and was obtained with 2 s saturation at 25 saturation frequency offsets omega = -6 to + 6 ppm (step 0.5 ppm). delta B-0 maps were acquired separately for a point-by-point delta B-0 correction. APT signal intensity (SI) was defined as magnetization transfer asymmetry at 3.5 ppm: magnetization transfer ratio (MTR)(asym) = (S[-3.5 ppm] -S[+ 3.5 ppm])/S-0. Regions of interest were carefully placed by 2 neuroradiologists in solid parts within brain tumors. The APT SI was compared with World Health Organization grade, Ki-67 labeling index (LI), and cell density. Results. The mean APT SI values were 2.1 +/- 0.4% in grade II gliomas (n = 8), 3.2 +/- 0.9% in grade III gliomas (n = 10), and 4.1 +/- 1.0% in grade IV gliomas (n = 18). Significant differences in APT intensity were observed between grades II and III (P < .05) and grades III and IV (P < .05), as well as between grades II and IV (P < .001). There were positive correlations between APT SI and Ki-67 LI (P = .01, R = 0.43) and between APT SI and cell density (P < .05, R = 0.38). The gliomas with microscopic necrosis showed higher APT SI than those without necrosis (P < .001). Conclusions. APT imaging can predict the histopathological grades of adult diffuse gliomas.

引用

页码：441 / 448

页数：8

共 35 条

[1] CEREBRAL BLOOD-VOLUME MAPS OF GLIOMAS - COMPARISON WITH TUMOR GRADE AND HISTOLOGIC-FINDINGS [J].