Causes and consequences of replication stress

被引：1461
作者：
Zeman, Michelle K. [1 ]
Cimprich, Karlene A. [1 ]
机构：
[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA
来源：
NATURE CELL BIOLOGY | 2014年 / 16卷 / 01期
基金：
美国国家卫生研究院;
关键词：
DNA-DAMAGE RESPONSE; COMMON FRAGILE SITES; MAINTAIN GENOME STABILITY; MEIER-GORLIN SYNDROME; FORK REVERSAL; RIBONUCLEOTIDE INCORPORATION; POSTREPLICATION REPAIR; SYNTHETIC LETHALITY; DORMANT ORIGINS; ATR ACTIVATION;
D O I：
10.1038/ncb2897
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.
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收藏
页码：2 / 9
页数：8
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