Causes and consequences of replication stress

被引：1461

作者：

Zeman, Michelle K. ^{[1
]}

Cimprich, Karlene A. ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Dept Chem & Syst Biol, Stanford, CA 94305 USA

来源：

NATURE CELL BIOLOGY | 2014年 / 16卷 / 01期

基金：

美国国家卫生研究院;

关键词：

DNA-DAMAGE RESPONSE; COMMON FRAGILE SITES; MAINTAIN GENOME STABILITY; MEIER-GORLIN SYNDROME; FORK REVERSAL; RIBONUCLEOTIDE INCORPORATION; POSTREPLICATION REPAIR; SYNTHETIC LETHALITY; DORMANT ORIGINS; ATR ACTIVATION;

D O I：

10.1038/ncb2897

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Replication stress is a complex phenomenon that has serious implications for genome stability, cell survival and human disease. Generation of aberrant replication fork structures containing single-stranded DNA activates the replication stress response, primarily mediated by the kinase ATR (ATM- and Rad3-related). Along with its downstream effectors, ATR stabilizes and helps to restart stalled replication forks, avoiding the generation of DNA damage and genome instability. Understanding this response may be key to diagnosing and treating human diseases caused by defective responses to replication stress.

引用

页码：2 / 9

页数：8

共 139 条

[1] Causes of Genome Instability [J].

Aguilera, Andres ;

Garcia-Muse, Tatiana .

ANNUAL REVIEW OF GENETICS, VOL 47, 2013, 47 :1-+

[2] R Loops: From Transcription Byproducts to Threats to Genome Stability [J].

Aguilera, Andres ;

Garcia-Muse, Tatiana .

MOLECULAR CELL, 2012, 46 (02) :115-124

[3] Senataxin Associates with Replication Forks to Protect Fork Integrity across RNA-Polymerase-II-Transcribed Genes [J].

Alzu, Amaya ;

Bermejo, Rodrigo ;

Begnis, Martina ;

Lucca, Chiara ;

Piccini, Daniele ;

Carotenuto, Walter ;

Saponaro, Marco ;

Brambati, Alessandra ;

Cocito, Andrea ;

Foiani, Marco ;

Liberi, Giordano .

CELL, 2012, 151 (04) :835-846

[4] Dynamics of DNA replication in mammalian somatic cells: Nucleotide pool modulates origin choice and interorigin spacing [J].

Anglana, M ;

Apiou, F ;

Bensimon, A ;

Debatisse, M .

CELL, 2003, 114 (03) :385-394

[5]

[Anonymous], CANC TREAT REV

[6] Replication stress and mechanisms of CNV formation [J].

Arlt, Martin F. ;

Wilson, Thomas E. ;

Glover, Thomas W. .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 2012, 22 (03) :204-210

[7] Codanin-1, mutated in the anaemic disease CDAI, regulates Asf1 function in S-phase histone supply [J].

Ask, Katrine ;

Jasencakova, Zuzana ;

Menard, Patrice ;

Feng, Yunpeng ;

Almouzni, Genevieve ;

Groth, Anja .

EMBO JOURNAL, 2012, 31 (08) :2013-2023

[8] The annealing helicase SMARCAL1 maintains genome integrity at stalled replication forks [J].

Bansbach, Carol E. ;

Betous, Remy ;

Lovejoy, Courtney A. ;

Glick, Gloria G. ;

Cortez, David .

GENES & DEVELOPMENT, 2009, 23 (20) :2405-2414

[9] Penetrance of biallelic SMARCAL1 mutations is associated with environmental and genetic disturbances of gene expression [J].

Baradaran-Heravi, Alireza ;

Cho, Kyoung Sang ;

Tolhuis, Bas ;

Sanyal, Mrinmoy ;

Morozova, Olena ;

Morimoto, Marie ;

Elizondo, Leah I. ;

Bridgewater, Darren ;

Lubieniecka, Joanna ;

Beirnes, Kimberly ;

Myung, Clara ;

Leung, Danny ;

Fam, Hok Khim ;

Choi, Kunho ;

Huang, Yan ;

Dionis, Kira Y. ;

Zonana, Jonathan ;

Keller, Kory ;

Stenzel, Peter ;

Mayfield, Christy ;

Luecke, Thomas ;

Bokenkamp, Arend ;

Marra, Marco A. ;

van Lohuizen, Maarten ;

Lewis, David B. ;

Shaw, Chad ;

Boerkoel, Cornelius F. .

HUMAN MOLECULAR GENETICS, 2012, 21 (11) :2572-2586

[10] Identification of Early Replicating Fragile Sites that Contribute to Genome Instability [J].

Barlow, Jacqueline H. ;

Faryabi, Robert B. ;

Callen, Elsa ;

Wong, Nancy ;

Malhowski, Amy ;

Chen, Hua Tang ;

Gutierrez-Cruz, Gustavo ;

Sun, Hong-Wei ;

McKinnon, Peter ;

Wright, George ;

Casellas, Rafael ;

Robbiani, Davide F. ;

Staudt, Louis ;

Fernandez-Capetillo, Oscar ;

Nussenzweig, Andre .

CELL, 2013, 152 (03) :620-632

← 1 2 3 4 5 6 7 8 9 10 →