Identification of a Novel HIV Type 1 Recombinant Form (CRF01_AE/CRF07_BC) in Men Who Have Sex with Men in Zhejiang, China

被引：1
作者：
Xu, Yufan [1 ]
Peng, Xiaorong [1 ]
Xie, Tiansheng [1 ]
Lu, Xiangyun [1 ]
Wu, Nanping [1 ]
机构：
[1] Zhejiang Univ, Sch Med, Affiliated Hosp 1,State Key Lab Diag & Treatment, Collaborat Innovat Ctr Diag & Treatment Infect Di, 79 Qingchun Rd, Hangzhou 310000, Zhejiang, Peoples R China
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 2017年 / 33卷 / 07期
基金：
国家高技术研究发展计划(863计划); 中国国家自然科学基金;
关键词：
HIV-1; MSM; recombinant forms; GENOMIC CHARACTERIZATION; SICHUAN;
D O I：
10.1089/aid.2017.0001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The prevalence of HIV-1 is increasing rapidly among the population of men who have sex with men (MSM) in China. Here, we report a novel HIV type 1 recombinant form consisting of CRF01_AE and CRF07_BC detected in a male patient through homosexual behavior. A phylogenic analysis revealed that this unique recombinant form (URF) exhibits a complex genomic structure with three CRF07_BC regions inserted into the CRF01_AE backbone. Recently, several second-generation recombinant forms (e.g., CRF01_AE/CRF07_BC) have been identified among MSM in China. The emergence of such URFs highlights the complexity of the HIV-1 epidemic among this population. Therefore, further molecular epidemiological investigation is required to track the genetic evolution of HIV-1 strains.
引用
收藏
页码：728 / 734
页数：7
相关论文
共 12 条
[1]   The increase in global HIV epidemics in MSM [J].
Beyrer, Chris ;
Sullivan, Patrick ;
Sanchez, Jorge ;
Baral, Stefan D. ;
Collins, Chris ;
Wirtz, Andrea L. ;
Altman, Dennis ;
Trapence, Gift ;
Mayer, Kenneth .
AIDS, 2013, 27 (17) :2665-2678
[2]   The origin and diversity of the HIV-1 pandemic [J].
Hemelaar, Joris .
TRENDS IN MOLECULAR MEDICINE, 2012, 18 (03) :182-192
[3]  
Li XG, 2013, AIDS RES HUM RETROV, V29, P1604, DOI [10.1089/aid.2013.0116, 10.1089/AID.2013.0116]
[4]  
Li Z, 2015, AIDS RES HUM RETROV, V31, P342, DOI [10.1089/AID.2014.0307, 10.1089/aid.2014.0307]
[5]   TTrends of HIV subtypes and phylogenetic dynamics among young men who have sex with men in China, 2009-2014 [J].
Li, Zheng ;
Liao, Lingjie ;
Feng, Yi ;
Zhang, Jing ;
Yan, Jing ;
He, Cui ;
Xu, Wei ;
Ruan, Yuhua ;
Xing, Hui ;
Shao, Yiming .
SCIENTIFIC REPORTS, 2015, 5
[6]   Selection for human immunodeficiency virus type 1 recombinants in a patient with rapid progression to AIDS [J].
Liu, SL ;
Mittler, JE ;
Nickle, DC ;
Mulvania, TM ;
Shriner, D ;
Rodrigo, AG ;
Kosloff, B ;
He, X ;
Corey, L ;
Mullins, JI .
JOURNAL OF VIROLOGY, 2002, 76 (21) :10674-10684
[7]  
Peng XR, 2016, AIDS RES HUM RETROV, V32, P900, DOI [10.1089/AID.2016.0114, 10.1089/aid.2016.0114]
[8]   Origins of HIV and the AIDS Pandemic [J].
Sharp, Paul M. ;
Hahn, Beatrice H. .
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE, 2011, 1 (01)
[9]  
Wang Y, 2016, AIDS RES HUM RETROV, V32, P718, DOI [10.1089/AID.2015.0276, 10.1089/aid.2015.0276]
[10]  
Wei HM, 2013, AIDS RES HUM RETROV, V29, P1173, DOI [10.1089/aid.2013.0104, 10.1089/AID.2013.0104]
12