HIV-1 rebound after anti-retroviral therapy

被引:43
作者
Ho, DD [1 ]
Zhang, LQ [1 ]
机构
[1] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA
关键词
D O I
10.1038/77447
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In patients with human immunodeficiency virus 1, a comparison of the genotype of rebounding virus to that In the latent reservoir after highly active anti-retroviral therapy is discontinued indicates that the latent reservoir is not the cause of viral rebound in most cases. However, the precise anatomic location of the source of viral rebound is still undefined (pages 757-761).
引用
收藏
页码:736 / 737
页数:2
相关论文
共 10 条
[1]   Relationship between pre-existing viral reservoirs and the re-emergence of plasma viremia after discontinuation of highly active anti-retroviral therapy [J].
Chun, TW ;
Davey, RT ;
Ostrowski, M ;
Justement, JS ;
Engel, D ;
Mullins, JI ;
Fauci, AS .
NATURE MEDICINE, 2000, 6 (07) :757-761
[2]   Quantification of latent tissue reservoirs and total body viral load in HIV-1 Infection [J].
Chun, TW ;
Carruth, L ;
Finzi, D ;
Shen, XF ;
DiGiuseppe, JA ;
Taylor, H ;
Hermankova, M ;
Chadwick, K ;
Margolick, J ;
Quinn, TC ;
Kuo, YH ;
Brookmeyer, R ;
Zeiger, MA ;
BarditchCrovo, P ;
Siliciano, RF .
NATURE, 1997, 387 (6629) :183-188
[3]   HIV-1 and T cell dynamics after interruption of highly active antiretroviral therapy (HAART) in patients with a history of sustained viral suppression [J].
Davey, RT ;
Bhat, N ;
Yoder, C ;
Chun, TW ;
Metcalf, JA ;
Dewar, R ;
Natarajan, V ;
Lempicki, RA ;
Adelsberger, JW ;
Millers, KD ;
Kovacs, JA ;
Polis, MA ;
Walker, RE ;
Falloon, L ;
Masur, H ;
Gee, D ;
Baseler, M ;
Dimitrov, DS ;
Fauci, AS ;
Lane, HC .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (26) :15109-15114
[4]   Latent infection of CD4+ T cells provides a mechanism for lifelong persistence of HIV-1, even in patients on effective combination therapy [J].
Finzi, D ;
Blankson, J ;
Siliciano, JD ;
Margolick, JB ;
Chadwick, K ;
Pierson, T ;
Smith, K ;
Lisziewicz, J ;
Lori, F ;
Flexner, C ;
Quinn, TC ;
Chaisson, RE ;
Rosenberg, E ;
Walker, B ;
Gange, S ;
Gallant, J ;
Siliciano, RF .
NATURE MEDICINE, 1999, 5 (05) :512-517
[5]   Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [J].
Finzi, D ;
Hermankova, M ;
Pierson, T ;
Carruth, LM ;
Buck, C ;
Chaisson, RE ;
Quinn, TC ;
Chadwick, K ;
Margolick, J ;
Brookmeyer, R ;
Gallant, J ;
Markowitz, M ;
Ho, DD ;
Richman, DD ;
Siliciano, RF .
SCIENCE, 1997, 278 (5341) :1295-1300
[6]   Persistence of HIV-1 transcription in peripheral-blood mononuclear cells in patients receiving potent antiretroviral therapy [J].
Furtado, MR ;
Callaway, DS ;
Phair, JP ;
Kunstman, KJ ;
Stanton, JL ;
Macken, CA ;
Perelson, AS ;
Wolinsky, SM .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (21) :1614-1622
[7]   Toward HIV eradication or remission: The tasks ahead [J].
Ho, DD .
SCIENCE, 1998, 280 (5371) :1866-1867
[8]   Decay characteristics of HIV-1-infected compartments during combination therapy [J].
Perelson, AS ;
Essunger, P ;
Cao, YZ ;
Vesanen, M ;
Hurley, A ;
Saksela, K ;
Markowitz, M ;
Ho, DD .
NATURE, 1997, 387 (6629) :188-191
[9]   The decay of the latent reservoir of replication-competent HIV-1 is inversely correlated with the extent of residual viral replication during prolonged anti-retroviral therapy [J].
Ramratnam, B ;
Mittler, JE ;
Zhang, LQ ;
Boden, D ;
Hurley, A ;
Fang, F ;
Macken, CA ;
Perelson, AS ;
Markowitz, M ;
Ho, DD .
NATURE MEDICINE, 2000, 6 (01) :82-85
[10]   Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy [J].
Zhang, LQ ;
Ramratnam, B ;
Tenner-Racz, K ;
He, YX ;
Vesanen, M ;
Lewin, S ;
Talal, A ;
Racz, P ;
Perelson, AS ;
Korber, BT ;
Markowitz, M ;
Ho, DD .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (21) :1605-1613