Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway

被引：300

作者：

Chow, CW

Rincon, M

Cavanagh, J

Dickens, M

Davis, RJ

机构：

[1] UNIV MASSACHUSETTS, SCH MED,HOWARD HUGHES MED INST,PROGRAM MOL MED, DEPT BIOCHEM & MOL BIOL, WORCESTER, MA 01605 USA

[2] UNIV VERMONT, DEPT MED, PROGRAM IMMUNOBIOL, BURLINGTON, VT 05405 USA

来源：

SCIENCE | 1997年 / 278卷 / 5343期

关键词：

D O I：

10.1126/science.278.5343.1638

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells, NFAT activation is mediated in part, by induced nuclear import, This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin, The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites, Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4, in contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.

引用

页码：1638 / 1641

页数：4

共 28 条

[1] Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3 [J].

Beals, CR ;

Sheridan, CM ;

Turck, CW ;

Gardner, P ;

Crabtree, GR .

SCIENCE, 1997, 275 (5308) :1930-1933

[2] Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interaction [J].

Beals, CR ;

Clipstone, NA ;

Ho, SN ;

Crabtree, GR .

GENES & DEVELOPMENT, 1997, 11 (07) :824-834

[3] T cell antigen receptor signal transduction pathways [J].

Cantrell, D .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :259-274

[4]

CHOW CW, UNPUB

[5]

CRABTREE GR, 1994, ANNU REV BIOCHEM, V63, P1045, DOI 10.1146/annurev.bi.63.070194.005145

[6] JNK1 - A PROTEIN-KINASE STIMULATED BY UV-LIGHT AND HA-RAS THAT BINDS AND PHOSPHORYLATES THE C-JUN ACTIVATION DOMAIN [J].

DERIJARD, B ;

HIBI, M ;

WU, IH ;

BARRETT, T ;

SU, B ;

DENG, TL ;

KARIN, M ;

DAVIS, RJ .

CELL, 1994, 76 (06) :1025-1037

[7] A cytoplasmic inhibitor of the JNK signal transduction pathway [J].

Dickens, M ;

Rogers, JS ;

Cavanagh, J ;

Raitano, A ;

Xia, ZG ;

Halpern, JR ;

Greenberg, ME ;

Sawyers, CL ;

Davis, RJ .

SCIENCE, 1997, 277 (5326) :693-696

[8] Binding of zinc finger protein ZPR1 to the epidermal growth factor receptor [J].

GalchevaGargova, Z ;

Konstantinov, KN ;

Wu, IH ;

Klier, FG ;

Barrett, T ;

Davis, RJ .

SCIENCE, 1996, 272 (5269) :1797-1802

[9] Multiple p21ras effector pathways regulate nuclear factor of activated T cells [J].

Genot, E ;

Cleverley, S ;

Henning, S ;

Cantrell, D .

EMBO JOURNAL, 1996, 15 (15) :3923-3933

[10] TRANSCRIPTION FACTOR ATF2 REGULATION BY THE JNK SIGNAL-TRANSDUCTION PATHWAY [J].

GUPTA, S ;

CAMPBELL, D ;

DERIJARD, B ;

DAVIS, RJ .

SCIENCE, 1995, 267 (5196) :389-393

← 1 2 3 →