Gene- and cell-based therapies for cardiovascular diseases: current status and future directions

被引：3
作者：
Melo, LG
Gnecchi, M
Pachori, AS
Wang, K
Dzau, VJ
机构：
[1] Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA 02115 USA
[3] Queens Univ, Kingston, ON K7L 3N6, Canada
来源：
EUROPEAN HEART JOURNAL SUPPLEMENTS | 2004年 / 6卷 / 0E期
关键词：
bone marrow; cardiac progenitors; cellular cardiomyoptasty; coronary artery disease; endothelial progenitor cells; heme oxygenase; protective gene therapy;
D O I：
10.1016/j.ehjsup.2004.06.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Recent advances in understanding the molecular and cellular basis of cardiovascular diseases, together with the availability of tools for genetic manipulation of the cardiovascular system, offer possibilities for new treatments. Gene therapies have demonstrated potential usefulness in treating complex diseases such as hypertension, atherosclerosis and myocardial ischaemia based on studies of various animal models. Some of these experimental therapies have transitioned into clinical trials to assess their safety, feasibility and therapeutic potential in humans with cardiovascular disease. The recent isolation of adult progenitor cells with the capacity to differentiate into endothelial and cardiomyocyte phenotypes has opened an exciting era of cell therapies for vascularization and repair of ischaemic tissues and injured blood vessels. Despite these significant developments, we believe that the successful translation of these experimental therapies into clinical practice will require safer and more effective vectors and delivery tools, a deeper knowledge of progenitor cell biology and, finally, the documentation of efficacy and safety through multicentre randomized trials. (C) 2004 Published by Elsevier Ltd on behalf of The European Society of Cardiology.
引用
收藏
页码：E24 / E35
页数：12
相关论文
共 154 条
[1]  
AGRAWAL RS, 2001, MOL THER, V3, pA837
[2]   Isolation of putative progenitor endothelial cells for angiogenesis [J].
Asahara, T ;
Murohara, T ;
Sullivan, A ;
Silver, M ;
vanderZee, R ;
Li, T ;
Witzenbichler, B ;
Schatteman, G ;
Isner, JM .
SCIENCE, 1997, 275 (5302) :964-967
[3]   Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization [J].
Asahara, T ;
Masuda, H ;
Takahashi, T ;
Kalka, C ;
Pastore, C ;
Silver, M ;
Kearne, M ;
Magner, M ;
Isner, JM .
CIRCULATION RESEARCH, 1999, 85 (03) :221-228
[4]   Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction -: (TOPCARE-AMI) [J].
Assmus, B ;
Schächinger, V ;
Teupe, C ;
Britten, M ;
Lehmann, R ;
Döbert, N ;
Grünwald, F ;
Aicher, A ;
Urbich, C ;
Martin, H ;
Hoelzer, D ;
Dimmeler, S ;
Zeiher, AM .
CIRCULATION, 2002, 106 (24) :3009-3017
[5]   Gene Therapy Progress and Prospects: Gene therapy in organ transplantation [J].
Bagley, J ;
Iacomini, J .
GENE THERAPY, 2003, 10 (08) :605-611
[6]  
BASHIR R, 2002, KIDNEY INT S1, V61, P110
[7]   Adult cardiac stem cells are multipotent and support myocardial regeneration [J].
Beltrami, AP ;
Barlucchi, L ;
Torella, D ;
Baker, M ;
Limana, F ;
Chimenti, S ;
Kasahara, H ;
Rota, M ;
Musso, E ;
Urbanek, K ;
Leri, A ;
Kajstura, J ;
Nadal-Ginard, B ;
Anversa, P .
CELL, 2003, 114 (06) :763-776
[8]   Mechanisms of angioplasty and stent restenosis: implications for design of rational therapy [J].
Bennett, MR ;
O'Sullivan, M .
PHARMACOLOGY & THERAPEUTICS, 2001, 91 (02) :149-166
[9]   Administration of granulocyte colony-stimulating factor enhances endothelialization and microvessel formation in small-caliber synthetic vascular grafts [J].
Bhattacharya, V ;
Shi, Q ;
Ishida, A ;
Sauvage, LR ;
Hammond, WP ;
Wu, MHD .
JOURNAL OF VASCULAR SURGERY, 2000, 32 (01) :116-122
[10]   Cell cycle progression - New therapeutic target for vascular proliferative disease [J].
Braun-Dullaeus, RC ;
Mann, MJ ;
Dzau, VJ .
CIRCULATION, 1998, 98 (01) :82-89
12345678910