MicroRNA-29: A Crucial Player in Fibrotic Disease

被引：74

作者：

Deng, Zhenjun ^{[1
]}

He, Yongjing ^{[1
,2
]}

Yang, Xujuan ^{[1
]}

Shi, Hang ^{[1
]}

Shi, Ao ^{[3
]}

Lu, Lechun ^{[1
,4
]}

He, Li ^{[1
]}

机构：

[1] Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China

[2] Kunming Med Univ, Affiliated Hosp 2, Dept Plast Surg, Kunming, Yunnan, Peoples R China

[3] Wheaton Coll, Dept Biochem, Norton, MA 02766 USA

[4] Kunming Med Univ, Dept Physiol, 1168 West Chunrong Rd,Yuhua Ave, Kunming 650500, Yunnan, Peoples R China

来源：

MOLECULAR DIAGNOSIS & THERAPY | 2017年 / 21卷 / 03期

基金：

中国国家自然科学基金;

关键词：

STELLATE CELL ACTIVATION; EXTRACELLULAR-MATRIX SYNTHESIS; IDIOPATHIC PULMONARY-FIBROSIS; POTENTIAL THERAPEUTIC TARGET; LIVER FIBROSIS; SYSTEMIC-SCLEROSIS; RENAL FIBROSIS; TISSUE FIBROSIS; GROWTH-FACTOR; MYSTERIOUS REGULATOR;

D O I：

10.1007/s40291-016-0253-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases.

引用

页码：285 / 294

页数：10

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