MicroRNA-29: A Crucial Player in Fibrotic Disease

被引：74
作者：
Deng, Zhenjun [1 ]
He, Yongjing [1 ,2 ]
Yang, Xujuan [1 ]
Shi, Hang [1 ]
Shi, Ao [3 ]
Lu, Lechun [1 ,4 ]
He, Li [1 ]
机构：
[1] Kunming Med Univ, Affiliated Hosp 1, Dept Dermatol, 295 Xichang Rd, Kunming 650032, Yunnan, Peoples R China
[2] Kunming Med Univ, Affiliated Hosp 2, Dept Plast Surg, Kunming, Yunnan, Peoples R China
[3] Wheaton Coll, Dept Biochem, Norton, MA 02766 USA
[4] Kunming Med Univ, Dept Physiol, 1168 West Chunrong Rd,Yuhua Ave, Kunming 650500, Yunnan, Peoples R China
来源：
MOLECULAR DIAGNOSIS & THERAPY | 2017年 / 21卷 / 03期
基金：
中国国家自然科学基金;
关键词：
STELLATE CELL ACTIVATION; EXTRACELLULAR-MATRIX SYNTHESIS; IDIOPATHIC PULMONARY-FIBROSIS; POTENTIAL THERAPEUTIC TARGET; LIVER FIBROSIS; SYSTEMIC-SCLEROSIS; RENAL FIBROSIS; TISSUE FIBROSIS; GROWTH-FACTOR; MYSTERIOUS REGULATOR;
D O I：
10.1007/s40291-016-0253-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Fibrosis is a common pathological state characterized by the excessive accumulation of extracellular matrix components, but the pathogenesis of the disease is still not clear. Previous studies have shown that microRNA-29 (miR-29) can play pivotal roles in the regulation of a variety of organ fibrosis, including cardiac fibrosis, hepatic fibrosis, lung fibrosis, systemic sclerosis, and keloid. In this review, we outline the structure, expression, and regulation of miR-29 as well as its role in fibrotic diseases.
引用
收藏
页码：285 / 294
页数：10
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