HIV and complement: hijacking an immune defense

被引：31

作者：

Datta, P. K. . ^{[1
]}

Rappaport, J. ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Dept Neurosci, Philadelphia, PA 19122 USA

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2006年 / 60卷 / 09期

基金：

美国国家卫生研究院;

关键词：

HIV; complement; C3; complement activation; NeuroAIDS; HIVAN;

D O I：

10.1016/j.biopha.2006.07.087

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The complement system is a central player of the innate immune system. Activation of the complement system protects the host against pathogens. However, uncontrolled synthesis can be detrimental to host. This concise review summarizes the current understanding of the mechanism(s) of complement activation, the mechanism of C3 regulation, and the role of complement in human immunodeficiency virus (HIV) pathogenesis with emphasis on the cross-talk between HIV and complement system in NeuroAIDS and HIV-associated nephropathy (HIVAN). (c) 2006 Elsevier Masson SAS. All rights reserved.

引用

页码：561 / 568

页数：8

共 71 条

[1] COMPLEMENT-DEPENDENT CYTOTOXICITY OF SENSORY GANGLION NEURONS MEDIATED BY THE GP120 GLYCOPROTEIN OF HIV-1 [J].

APOSTOLSKI, S ;

MCALARNEY, T ;

HAYS, AP ;

LATOV, N .

IMMUNOLOGICAL INVESTIGATIONS, 1994, 23 (01) :47-52

[2] HIV-1 induces human monocyte-derived macrophages to produce C3 and to fix C3 on their surface [J].

Bajtay, Z ;

Kacani, L ;

Erdei, A ;

Dierich, MP .

JOURNAL OF LEUKOCYTE BIOLOGY, 1998, 63 (04) :463-468

[3] Cutting edge: Productive HIV-1 infection of dendritic cells via complement receptor type 3 (CR3, CD11b/CD18) [J].

Bajtay, Z ;

Speth, C ;

Erdei, A ;

Dierich, MP .

JOURNAL OF IMMUNOLOGY, 2004, 173 (08) :4775-4778

[4] Complement dependent trapping of infectious HIV in human lymphoid tissues [J].

Bánki, Z ;

Kacani, L ;

Rusert, P ;

Pruenster, M ;

Wilflingseder, D ;

Falkensammer, B ;

Stellbrink, HJ ;

van Lunzen, J ;

Trkola, A ;

Dierich, MP ;

Stoiber, H .

AIDS, 2005, 19 (05) :481-486

[5] Opsonization of HIV-1 by semen complement enhances infection of human epithelial cells [J].

Bouhlal, H ;

Chomont, N ;

Haeffner-Cavaillon, N ;

Kazatchkine, MD ;

Belec, L ;

Hocini, H .

JOURNAL OF IMMUNOLOGY, 2002, 169 (06) :3301-3306

[6] Soluble CD16 inhibits CR3 (CD11b/CD18)-mediated infection of monocytes/macrophages by opsonized primary R5 HIV-1 [J].

Bouhlal, H ;

Galon, J ;

Kazatchkine, MD ;

Fridman, WH ;

Sautès-Fridman, C ;

Cavaillon, NH .

JOURNAL OF IMMUNOLOGY, 2001, 166 (05) :3377-3383

[7] COMPLEMENT MEDIATES HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION OF A HUMAN T-CELL LINE IN A CD4-INDEPENDENT AND ANTIBODY-INDEPENDENT FASHION [J].

BOYER, V ;

DESGRANGES, C ;

TRABAUD, MA ;

FISCHER, E ;

KAZATCHKINE, MD .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 173 (05) :1151-1158

[8] HIV-1 induces complement factor C3 synthesis in astrocytes and neurons by modulation of promoter activity [J].

Bruder, C ;

Hagleitner, M ;

Darlington, G ;

Mohsenipour, I ;

Würzner, R ;

Höllmüller, I ;

Stoiber, H ;

Lass-Flörl, C ;

Dierich, MP ;

Speth, C .

MOLECULAR IMMUNOLOGY, 2004, 40 (13) :949-961

[9] CD40 ligand increases complement C3 secretion by proximal tubular epithelial cells [J].

Castellano, G ;

Cappiello, V ;

Fiore, N ;

Pontrelli, P ;

Gesualdo, L ;

Schena, FP ;

Montinaro, V .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2005, 16 (07) :2003-2011

[10] Expression of complement inhibitor protein CD59 in human neuronal and glial cell lines treated with HIV-1 gp41 peptides [J].

Chong, YH ;

Lee, MJ .

JOURNAL OF NEUROVIROLOGY, 2000, 6 (01) :51-60

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