Cobalt-catalyzed electrochemical C-H/N-H functionalization of N-(quinolin-8-yl)benzamide with isocyanides

被引：34

作者：

Chen, Jinkang ^{[1
]}

Jin, Licheng ^{[2
]}

Zhou, Jian ^{[2
]}

Jiang, Xinpeng ^{[2
]}

Yu, Chuanming ^{[1
,2
]}

机构：

[1] Zhejiang Univ Technol, Collaborat Innovat Ctr Yangtze River Delta Reg Gr, Hangzhou 310014, Zhejiang, Peoples R China

[2] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China

来源：

TETRAHEDRON LETTERS | 2019年 / 60卷 / 31期

基金：

中国国家自然科学基金;

关键词：

Electrochemistry; C-H functionalization; Cobalt; Isocyanide; Oxidant-free; EFFICIENT SYNTHESIS; BOND FUNCTIONALIZATIONS; ACTIVATION; INDOLES; DERIVATIVES; ANNULATION; INSERTION; ISONITRILES; BENZAMIDES; CYANATION;

D O I：

10.1016/j.tetlet.2019.06.060

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of functionalized iminoisoindolinone derivatives has been achieved via a mild electrochemical oxidative C-H/N-H functionalizationfintramolecular annulations with isocyanides in undivided cell equipped with a nickel cathode. In the presence of earth abundant cobalt catalyst, versatile iminoisoindolinone derivatives obtained in good yields and in a sustainable manner by using electricity as an oxidant in place of stoichiometric amount of silver and copper salts. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：2054 / 2058

页数：5

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