Polymorphisms at long non-coding RNAs and prostate cancer risk in an eastern Chinese population

被引：18

作者：

Cao, D-L ^{[1
,2
]}

Gul, C-Y ^{[1
,2
]}

Zhu, Y. ^{[1
,2
]}

Dai, B. ^{[1
,2
]}

Zhang, H-L ^{[1
,2
]}

Shi, G-H ^{[1
,2
]}

Shen, Y-J ^{[1
,2
]}

Zhu, Y-P ^{[1
,2
]}

Ma, C-G ^{[1
,2
]}

Xiao, W-J ^{[1
,2
]}

Qin, X-J ^{[1
,2
]}

Lin, G-W ^{[1
,2
]}

Ye, D-W ^{[1
,2
]}

机构：

[1] Fudan Univ, Shanghai Canc Ctr, Dept Urol, Shanghai 200032, Peoples R China

[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai 200032, Peoples R China

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2014年 / 17卷 / 04期

基金：

中国国家自然科学基金;

关键词：

GENOME-WIDE ASSOCIATION; CIGARETTE-SMOKING; MEN; REPLICATION; DIAGNOSIS; MORTALITY; FAMILIES; LOCI; 8Q24;

D O I：

10.1038/pcan.2014.34

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BACKGROUND: Controversial data on the association of single-nucleotide polymorphisms (SNPs, rs3787016G > A and rs10773338G > A) in long non-coding RNA (IncRNA) with prostate cancer risk were emerged. Considering possible genetic differences among populations, we conducted the present study to clarify these discrepancies and re-validate these results in an eastern Chinese population and thus provide clues for new therapeutic targets of prostate cancer. METHODS: Genotypes of these two SNPs from 1015 ethnic Han Chinese patients with prostate cancer and 1032 cancer-free controls were determined by Taqman assays. Logistic regression models were used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for risk associations. RESULTS: The association of rs3787016 A variant genotypes with a significantly higher prostate cancer risk were found (adjusted OR = 1.418, 95% CI = 1.090-1.844 for AA vs GG). Stratification analysis indicated that the risk of rs3787016 variant AG/AA genotypes was more evident in younger subjects, ever smoking, patients with Gleason score >= 7(4+3) and highly aggressive status. All these risks were not present for rs10773338G > A. CONCLUSIONS: These findings suggested that IncRNA SNPs may contribute to prostate cancer risk in an eastern Chinese population. Larger and well-designed studies with different ethnic populations are warranted to validate our findings.

引用

页码：315 / 319

页数：5

共 32 条

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