Functional status declines among cancer survivors: Trajectory and contributing factors

被引:66
作者
Petrick, Jessica L. [1 ]
Reeve, Bryce B. [2 ]
Kucharska-Newton, Anna M. [1 ]
Foraker, Randi E. [3 ]
Platz, Elizabeth A. [4 ]
Stearns, Sally C. [2 ]
Han, Xuesong [5 ]
Windham, B. Gwen [6 ]
Irwin, Debra E. [1 ]
机构
[1] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
[2] Univ N Carolina, Dept Hlth Policy & Management, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27599 USA
[3] Ohio State Univ, Div Epidemiol, Coll Publ Hlth, Columbus, OH 43210 USA
[4] Johns Hopkins Univ, Dept Epidemiol, Johns Hopkins Bloomberg Sch Publ Hlth, Baltimore, MD USA
[5] Amer Canc Soc, Atlanta, GA 30329 USA
[6] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA
关键词
Cancer survivorship; Functional status; Health-related quality of life; Longitudinal studies; QUALITY-OF-LIFE; CELL LUNG-CANCER; SELF-RATED HEALTH; ATHEROSCLEROSIS RISK; PHYSICAL FUNCTION; OLDER AMERICANS; PROSTATE-CANCER; BREAST-CANCER; IMPACT; PATTERNS;
D O I
10.1016/j.jgo.2014.06.002
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: This study aimed to quantify functional status (FS) trajectories pre- and post-diagnosis of cancer, FS trajectories among cancer-free individuals, and factors affecting FS. Materials and Methods: Self-reported FS, scored from 0 (worst) to 100 (best), of Atherosclerosis Risk in Communities (ARIC) Study cohort participants diagnosed with incident cancer (lung (N = 303), breast (N = 374), prostate (N = 529), colorectal (N = 228)), and cancer-free participants (N = 11,155) over 15 years was examined. FS was evaluated in two ways: 1) until death or follow-up year 15 (Model 1) and 2) same as survivorship model except that a FS value of zero was used for assessments after death to follow-up year 15 (Model 2). Mean FS at discrete time points were used to generate FS trajectories. Differences in repeated measures of FS were assessed using linear growth models. Results: Within one year after diagnosis, FS scores declined compared to the cancer-free group, except for prostate cancer. FS continued to decline beyond one year after lung or colorectal cancer diagnosis. FS was lower in all cancer groups, except prostate, compared to the cancer-free group (Model 1: lung 4.76, breast -2.28, colorectal -2.55; Model 2: lung -2.36, breast -2.46, colorectal -2.31). Predictors of decreased FS score independent of cancer diagnosis included low education, comorbidities, obesity, smoking, lack of health insurance, and age. Conclusion: FS in all incident cancer groups declined during the first year post-diagnosis, which could be due to intensive treatments. Targeting factors related to FS declines could improve health outcomes for patients with cancer. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:359 / 367
页数:9
相关论文
共 41 条
[1]  
[Anonymous], 2013, ATHEROSCLEROSIS RISK
[2]  
BAECKE JAH, 1982, AM J CLIN NUTR, V36, P936
[3]   Prostate cancer epidemiology in the United States [J].
Brawley, Otis W. .
WORLD JOURNAL OF UROLOGY, 2012, 30 (02) :195-200
[4]   Karnofsky and ECOG performance status scoring in lung cancer: A prospective, longitudinal study of 536 patients from a single institution [J].
Buccheri, G ;
Ferrigno, D ;
Tamburini, M .
EUROPEAN JOURNAL OF CANCER, 1996, 32A (07) :1135-1141
[5]   The impact of type 2 diabetes mellitus on daily functioning [J].
de Grauw, WJC ;
van de Lisdonk, EH ;
Behr, RRA ;
van Gerwen, WHEM ;
van den Hoogen, HJM ;
van Weel, C .
FAMILY PRACTICE, 1999, 16 (02) :133-139
[6]  
DEGRAUW WJC, 1995, DIABETIC MED, V12, P117
[7]   Patterns of self-rated health in older adults before and after sentinel health events [J].
Diehr, P ;
Williamson, J ;
Patrick, DL ;
Bild, DE ;
Burke, GL .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2001, 49 (01) :36-44
[8]   SELF-REPORTED CAUSES OF PHYSICAL-DISABILITY IN OLDER-PEOPLE - THE CARDIOVASCULAR HEALTH STUDY [J].
ETTINGER, WH ;
FRIED, LP ;
HARRIS, T ;
SHEMANSKI, L ;
SCHULZ, R ;
ROBBINS, J .
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 1994, 42 (10) :1035-1044
[9]   Socioeconomic status and the trajectory of self-rated health [J].
Foraker, Randi E. ;
Rose, Kathryn M. ;
Chang, Patricia P. ;
McNeill, Ann M. ;
Suchindran, Chirayath M. ;
Selvin, Elizabeth ;
Rosamond, Wayne D. .
AGE AND AGEING, 2011, 40 (06) :706-711
[10]   Functional status and the elderly cancer patient [J].
Garman, KS ;
Cohen, HJ .
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY, 2002, 43 (03) :191-208