Water-soluble inclusion complex of fullerene with γ-cyclodextrin polymer for photodynamic therapy

被引：57

作者：

Zhang, Wang ^{[1
,2
,3
]}

Gong, Xiangdong ^{[1
]}

Liu, Chang ^{[4
]}

Piao, Yuanzhe ^{[2
]}

Sun, Yun ^{[4
]}

Diao, Guowang ^{[1
]}

机构：

[1] Yangzhou Univ, Coll Chem & Chem Engn, Yangzhou 225002, Peoples R China

[2] Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Seoul 151742, South Korea

[3] Adv Inst Convergence Technol, Suwon 443270, South Korea

[4] Yangzhou Univ, Coll Med, Yangzhou 225002, Jiangsu, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2014年 / 2卷 / 31期

基金：

中国国家自然科学基金;

关键词：

SINGLET OXYGEN GENERATION; BETA-CYCLODEXTRIN; PHOTOPHYSICAL PROPERTIES; STATE PROPERTIES; C-60; DERIVATIVES; DRUG; KERATINOCYTES; NANOPARTICLES; ADSORPTION;

D O I：

10.1039/c4tb00560k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A stable aqueous inclusion complex of fullerene (C60) with macromolecules (C60 concentration as high as 3 x 10(-4) mol L-1) was achieved by a one-step strategy using gamma-cyclodextrin polymer (gamma-CDP). The inclusion complex of C60 with gamma-CDP (C60-gamma-CDP) was characterized by ultraviolet-visible, Raman and H-1-NMR spectroscopies, powder X-ray diffraction analysis, and thermogravimetric analysis. The supramolecular interactions and the equilibrium constant for a 1:2 (C60 : CD unit in gamma-CDP) complex of C60 with gamma-CDP were studied. Under ultraviolet A (UVA) irradiation C60-gamma-CDP in water could generate singlet oxygen, which was detected by electron paramagnetic resonance spectroscopy. We also evaluated the cytotoxicities of C60-gamma-CDP, and investigated the phototoxicity of C60-gamma-CDP and pristine C60 toward B16-F10 melanoma cells. The cell viability test showed that C60-gamma-CDP had a significantly higher photodynamic ability than that of the pristine C60 under UVA irradiation. This work demonstrated both a CDP-functionalized strategy for enhancing the water-solubility and phototoxicity of fullerenes for applications in cancer photodynamic therapy, as well as remediating the negative biological effects of pristine fullerenes.

引用

页码：5107 / 5115

页数：9

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