Total synthesis of panicein A2

被引：2
|
作者：
Yeung, Lili [1 ]
Pilkington, Lisa I. [1 ]
Cadelis, Melissa M. [1 ]
Copp, Brent R. [1 ]
Barker, David [1 ]
机构：
[1] Univ Auckland, Sch Chem Sci, Auckland 1, New Zealand
来源：
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 11卷
关键词：
modified Claisen rearrangement; sesquiterpene; chromenol; total synthesis; BIOMIMETIC TOTAL-SYNTHESIS; SESQUITERPENOIDS; REARRANGEMENT; DERIVATIVES; OXIDATION; ETHERS;
D O I：
10.3762/bjoc.11.215
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The first total synthesis of the unusual aromatic sesquiterpene panicein A(2) is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A2 exhibits very little antiproliferative activity at 10 mu M - an observation that is at odds with the earlier report that stated panicein A2 exhibits in vitro cytotoxicity against a number of tumour cell lines.
引用
收藏
页码：1991 / 1996
页数：6
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