Total synthesis of panicein A2

被引：2

作者：

Yeung, Lili ^{[1
]}

Pilkington, Lisa I. ^{[1
]}

Cadelis, Melissa M. ^{[1
]}

Copp, Brent R. ^{[1
]}

Barker, David ^{[1
]}

机构：

[1] Univ Auckland, Sch Chem Sci, Auckland 1, New Zealand

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2015年 / 11卷

关键词：

modified Claisen rearrangement; sesquiterpene; chromenol; total synthesis; BIOMIMETIC TOTAL-SYNTHESIS; SESQUITERPENOIDS; REARRANGEMENT; DERIVATIVES; OXIDATION; ETHERS;

D O I：

10.3762/bjoc.11.215

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first total synthesis of the unusual aromatic sesquiterpene panicein A(2) is reported and the structure of the natural product has been confirmed. When tested by the NCI against a range of human cancer cell lines, it was found that panicein A2 exhibits very little antiproliferative activity at 10 mu M - an observation that is at odds with the earlier report that stated panicein A2 exhibits in vitro cytotoxicity against a number of tumour cell lines.

引用

页码：1991 / 1996

页数：6

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