Two new naphthoquinones with antiviral activity from Rhinacanthus nasutus

被引：95

作者：

Sendl, A

Chen, JL

Jolad, SD

Stoddart, C

Rozhon, E

Kernan, M

Nanakorn, W

Balick, M

机构：

[1] SHAMAN PHARMACEUT,S SAN FRANCISCO,CA 94080

[2] BOT GARDEN ORG,CHIANG MAI,THAILAND

[3] NEW YORK BOT GARDEN,INST ECON BOT,BRONX,NY 10458

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 08期

关键词：

D O I：

10.1021/np9601871

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new naphthoquinones, rhinacanthin-C (1) and rhinacanthin-D (2), exhibit inhibitory activity against cytomegalovirus (CMV), with EC(50) values of 0.02 and 0.22 mu g/mL, respectively, against human CMV. They were isolated from the medicinal plant Rhinacanthus nasutus (Acanthaceae). The structures of the compounds were determined by analysis of their spectroscopic data, in particular, 2D NMR.

引用

页码：808 / 811

页数：4

共 20 条

[1]

BEHNKE J, ALDRICH LIB 13C 1H F, V2, pA910

[2]

BREITMAIER E, 1990, CARBON 13 NMR SPECTR, P327

[3] QUINONES .8. DEHYDRO-ALPHA- AND -BETA-LAPACHONE [J].

BURNETT, AR ;

THOMSON, RH .

JOURNAL OF THE CHEMICAL SOCIETY C-ORGANIC, 1967, (14) :1261-&

[4] STUDIES ON QUINONES .8. THE APPLICATION OF MICHAEL ADDUCTS FROM 2-HYDROXY-1,4-NAPHTHOQUINONES FOR THE PREPARATION OF DIHYDRONAPHTHOPYRANDIONES [J].

CASSIS, R ;

TAPIA, R ;

VALDERRAMA, J .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1982, 19 (02) :381-384

[5]

DAC AH, 1979, DUOC HOC, V3, P12

[6]

Dowdle WN, 1979, DIAGNOSTIC PROCEDURE, P585

[7] HYDROXYNAPHTHOQUINONES .2. CYCLIZATION AND THE BASICITY AND INTERCONVERSION OF ORTHO-QUINONES AND PARA-QUINONES [J].

ETTLINGER, MG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1950, 72 (07) :3090-3095

[8] ISOLATION AND IDENTIFICATION OF AN ANTIFUNGAL NAPHTHOPYRAN DERIVATIVE FROM RHINACANTHUS-NASUTUS [J].

KODAMA, O ;

ICHIKAWA, H ;

AKATSUKA, T ;

SANTISOPASRI, V ;

KATO, A ;

HAYASHI, Y .

JOURNAL OF NATURAL PRODUCTS, 1993, 56 (02) :292-294

[9] A REVISED STRUCTURE FOR RHINACANTHONE [J].

KUWAHARA, S ;

AWAI, N ;

KODAMA, O ;

HOWIE, RA ;

THOMSON, RH .

JOURNAL OF NATURAL PRODUCTS-LLOYDIA, 1995, 58 (09) :1455-1458

[10] SYNTHESIS OF AN ANTIFUNGAL NAPHTHOPYRAN DERIVATIVE ISOLATED FROM RHINACANTHUS-NASUTUS (ACANTHACEAE) [J].

KUWAHARA, S ;

NEMOTO, A ;

HIRAMATSU, A .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1991, 55 (11) :2909-2911

← 1 2 →